1-(2-chlorobenzyl)-2-[1-(4-isobutylphenyl)-1-methylethyl]-1H-benzimidazole

Base Information

• Chemical Name: 1-(2-chlorobenzyl)-2-[1-(4-isobutylphenyl)-1-methylethyl]-1H-benzimidazole
• CAS No.: 1382488-06-3
• Molecular Formula: C₂₇H₂₉ClN₂
• Molecular Weight: 416.994
• Mol file: 1382488-06-3.mol

Synonyms:1-(2-chlorobenzyl)-2-[1-(4-isobutylphenyl)-1-methylethyl]-1H-benzimidazole

Chemical Property of 1-(2-chlorobenzyl)-2-[1-(4-isobutylphenyl)-1-methylethyl]-1H-benzimidazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(2-chlorobenzyl)-2-[1-(4-isobutylphenyl)-1-methylethyl]-1H-benzimidazole

There total 5 articles about 1-(2-chlorobenzyl)-2-[1-(4-isobutylphenyl)-1-methylethyl]-1H-benzimidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

2-(2-(4-isobutylphenyl)propan-2-yl)-1H-benzimidazole (1382488-04-1) + 1-bromomethyl-2-chlorobenzene (611-17-6) → 1-(2-chlorobenzyl)-2-[1-(4-isobutylphenyl)-1-methylethyl]-1H-benzimidazole (1382488-06-3)

Guidance literature:

2-(2-(4-isobutylphenyl)propan-2-yl)-1H-benzimidazole; With potassium hydroxide; In dimethyl sulfoxide; at 20 ℃; for 0.5h;

1-bromomethyl-2-chlorobenzene; In dimethyl sulfoxide; at 20 ℃; for 3h;

DOI:10.1016/j.bmc.2012.04.048

Reference yield:

2–(4-isobutylphenyl)-2-methylpropanoic acid (95499-72-2) → 1-(2-chlorobenzyl)-2-[1-(4-isobutylphenyl)-1-methylethyl]-1H-benzimidazole (1382488-06-3)

Guidance literature:

Multi-step reaction with 3 steps

1.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C

2.1: acetic acid / 4 h / Reflux

3.1: potassium hydroxide / dimethyl sulfoxide / 0.5 h / 20 °C

3.2: 3 h / 20 °C

With dmap; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; potassium hydroxide; In dichloromethane; dimethyl sulfoxide;

DOI:10.1016/j.bmc.2012.04.048

Reference yield:

1,2-diamino-benzene (95-54-5) → 1-(2-chlorobenzyl)-2-[1-(4-isobutylphenyl)-1-methylethyl]-1H-benzimidazole (1382488-06-3)

Guidance literature:

Multi-step reaction with 3 steps

1.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C

2.1: acetic acid / 4 h / Reflux

3.1: potassium hydroxide / dimethyl sulfoxide / 0.5 h / 20 °C

3.2: 3 h / 20 °C

With dmap; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; potassium hydroxide; In dichloromethane; dimethyl sulfoxide;

DOI:10.1016/j.bmc.2012.04.048

upstream raw materials:

N-(2-aminophenyl)-2-(4-isobutylphenyl)-2-methylpropanamide

2-(2-(4-isobutylphenyl)propan-2-yl)-1H-benzimidazole

1-bromomethyl-2-chlorobenzene

(+/-)-ibuprofen methyl ester