N-(2-aminophenyl)-2-(4-isobutylphenyl)-2-methylpropanamide

Base Information

• Chemical Name: N-(2-aminophenyl)-2-(4-isobutylphenyl)-2-methylpropanamide
• CAS No.: 1382488-02-9
• Molecular Formula: C₂₀H₂₆N₂O
• Molecular Weight: 310.439
• Mol file: 1382488-02-9.mol

Synonyms:N-(2-aminophenyl)-2-(4-isobutylphenyl)-2-methylpropanamide

Chemical Property of N-(2-aminophenyl)-2-(4-isobutylphenyl)-2-methylpropanamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(2-aminophenyl)-2-(4-isobutylphenyl)-2-methylpropanamide

There total 2 articles about N-(2-aminophenyl)-2-(4-isobutylphenyl)-2-methylpropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

2–(4-isobutylphenyl)-2-methylpropanoic acid (95499-72-2) + 1,2-diamino-benzene (95-54-5) → N-(2-aminophenyl)-2-(4-isobutylphenyl)-2-methylpropanamide (1382488-02-9)

Guidance literature:

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃;

DOI:10.1016/j.bmc.2012.04.048

Reference yield:

ibuprofen (15687-27-1,58560-75-1) → N-(2-aminophenyl)-2-(4-isobutylphenyl)-2-methylpropanamide (1382488-02-9)

Guidance literature:

Multi-step reaction with 4 steps

1.1: thionyl chloride / 6 h / 0 - 20 °C

2.1: n-butyllithium; diisopropylamine / tetrahydrofuran; hexane / -78 - 0 °C

2.2: 1 h / 0 °C

3.1: N-benzyl-trimethylammonium hydroxide / methanol; water / 3.5 h / 75 °C

4.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C

With dmap; n-butyllithium; thionyl chloride; N-benzyl-trimethylammonium hydroxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; diisopropylamine; In tetrahydrofuran; methanol; hexane; dichloromethane; water;

DOI:10.1016/j.bmc.2012.04.048

Reference yield:

N-(2-aminophenyl)-2-(4-isobutylphenyl)-2-methylpropanamide (1382488-02-9) → 2-(2-(4-isobutylphenyl)propan-2-yl)-1H-benzimidazole (1382488-04-1)

Guidance literature:

With acetic acid; for 4h; Reflux;

DOI:10.1016/j.bmc.2012.04.048

upstream raw materials:

ibuprofen

2–(4-isobutylphenyl)-2-methylpropanoic acid

1,2-diamino-benzene

Downstream raw materials:

1-(2-chlorobenzyl)-2-[1-(4-isobutylphenyl)-1-methylethyl]-1H-benzimidazole

2-(2-(4-isobutylphenyl)propan-2-yl)-1H-benzimidazole