5-[2-({6-[(2-hydroxyethyl)(methyl)amino]pyridin-3-yl}amino)pyrimidin-4-yl]-2-(tetrahydro-2H-pyran-4-yloxy)benzonitrile

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Chemical Name:5-[2-({6-[(2-hydroxyethyl)(methyl)amino]pyridin-3-yl}amino)pyrimidin-4-yl]-2-(tetrahydro-2H-pyran-4-yloxy)benzonitrile
CAS No.:1403246-79-6
Molecular Formula:C₂₄H₂₆N₆O₃
Molecular Weight:446.509
Hs Code.:

Synonyms:5-[2-({6-[(2-hydroxyethyl)(methyl)amino]pyridin-3-yl}amino)pyrimidin-4-yl]-2-(tetrahydro-2H-pyran-4-yloxy)benzonitrile

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Chemical Property of 5-[2-({6-[(2-hydroxyethyl)(methyl)amino]pyridin-3-yl}amino)pyrimidin-4-yl]-2-(tetrahydro-2H-pyran-4-yloxy)benzonitrile

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Technology Process of 5-[2-({6-[(2-hydroxyethyl)(methyl)amino]pyridin-3-yl}amino)pyrimidin-4-yl]-2-(tetrahydro-2H-pyran-4-yloxy)benzonitrile

There total 6 articles about 5-[2-({6-[(2-hydroxyethyl)(methyl)amino]pyridin-3-yl}amino)pyrimidin-4-yl]-2-(tetrahydro-2H-pyran-4-yloxy)benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 16.0%

: 4928-46-5
2-((5-aminopyridin-2-yl)(methyl)amino)ethanol

: 1292317-55-5
5-(2-chloropyrimidin-4-yl)-2-(tetrahydro-2H-pyran-4-yloxy)benzonitrile

: 1403246-79-6
5-[2-({6-[(2-hydroxyethyl)(methyl)amino]pyridin-3-yl}amino)pyrimidin-4-yl]-2-(tetrahydro-2H-pyran-4-yloxy)benzonitrile

Guidance literature:: With caesium carbonate; palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In 1,4-dioxane; at 90 ℃; for 14h; Inert atmosphere;

Reference yield:

: 2081-44-9
Tetrahydro-pyran-4-ol

: 1403246-79-6
5-[2-({6-[(2-hydroxyethyl)(methyl)amino]pyridin-3-yl}amino)pyrimidin-4-yl]-2-(tetrahydro-2H-pyran-4-yloxy)benzonitrile

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 16 h / 0 - 45 °C

1.2: 20 °C

2.1: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 20 h / 80 °C

3.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / acetonitrile; water / 16 h / 90 °C

4.1: caesium carbonate / palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / 1,4-dioxane / 14 h / 90 °C / Inert atmosphere

With potassium acetate; sodium hydride; potassium carbonate; caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In 1,4-dioxane; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 40530-18-5
5-bromo-2-hydroxybenzonitrile

: 1403246-79-6
5-[2-({6-[(2-hydroxyethyl)(methyl)amino]pyridin-3-yl}amino)pyrimidin-4-yl]-2-(tetrahydro-2H-pyran-4-yloxy)benzonitrile

Guidance literature:: Multi-step reaction with 4 steps

1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 18 h / 20 °C

2: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 20 h / 80 °C

3: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / acetonitrile; water / 16 h / 90 °C

4: caesium carbonate / palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / 1,4-dioxane / 14 h / 90 °C / Inert atmosphere

With potassium acetate; potassium carbonate; caesium carbonate; triphenylphosphine; diethylazodicarboxylate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In tetrahydrofuran; 1,4-dioxane; water; acetonitrile;