4-(2,6-diethyl-4-methylphenyl)-2,6-dimethyl-5-phenoxy-2,3-dihydro-3-pyridazinone

Base Information

Chemical Name:4-(2,6-diethyl-4-methylphenyl)-2,6-dimethyl-5-phenoxy-2,3-dihydro-3-pyridazinone
CAS No.:1363808-49-4
Molecular Formula:C₂₃H₂₆N₂O₂
Molecular Weight:362.472
Hs Code.:

Synonyms:4-(2,6-diethyl-4-methylphenyl)-2,6-dimethyl-5-phenoxy-2,3-dihydro-3-pyridazinone

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Chemical Property of 4-(2,6-diethyl-4-methylphenyl)-2,6-dimethyl-5-phenoxy-2,3-dihydro-3-pyridazinone

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Technology Process of 4-(2,6-diethyl-4-methylphenyl)-2,6-dimethyl-5-phenoxy-2,3-dihydro-3-pyridazinone

There total 14 articles about 4-(2,6-diethyl-4-methylphenyl)-2,6-dimethyl-5-phenoxy-2,3-dihydro-3-pyridazinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1363806-83-0
4-(2,6-diethyl-4-methylphenyl)-2,6-dimethyl-5-methylsulfonyl-2,3-dihydro-3-pyridazinone

: 108-95-2,27073-41-2
phenol

: 1363808-49-4
4-(2,6-diethyl-4-methylphenyl)-2,6-dimethyl-5-phenoxy-2,3-dihydro-3-pyridazinone

Guidance literature:: phenol; With sodium hydride; In toluene; mineral oil; at 20 ℃; for 0.0833333h;

4-(2,6-diethyl-4-methylphenyl)-2,6-dimethyl-5-methylsulfonyl-2,3-dihydro-3-pyridazinone; at 20 - 100 ℃; for 3h;

N-benzyl-N,N,N-triethylammonium chloride; for 1.5h;

Reference yield:

: 314084-61-2
1-bromo-2,6-diethyl-4-methylbenzene

: 1363808-49-4
4-(2,6-diethyl-4-methylphenyl)-2,6-dimethyl-5-phenoxy-2,3-dihydro-3-pyridazinone

Guidance literature:: Multi-step reaction with 6 steps

1.1: magnesium; ethylene dibromide / toluene; tetrahydrofuran / 52 h / 40 - 50 °C / Inert atmosphere

1.2: 2 h / 0 - 5 °C / Inert atmosphere

2.1: sodium hydroxide; water / tetrahydrofuran / 3 h / 10 - 20 °C

3.1: thionyl chloride / N,N-dimethyl-formamide / toluene / 2 h / 50 °C / Inert atmosphere

4.1: triethylamine / toluene; acetonitrile / 2.5 h / 0 - 1 °C / Inert atmosphere

5.1: potassium carbonate / methanol / 3 h / Cooling with ice

6.1: sodium hydride / toluene; mineral oil / 0.08 h / 20 °C

6.2: 3 h / 20 - 100 °C

6.3: 1.5 h

With thionyl chloride; water; sodium hydride; potassium carbonate; magnesium; ethylene dibromide; triethylamine; sodium hydroxide; N,N-dimethyl-formamide; In tetrahydrofuran; methanol; toluene; acetonitrile; mineral oil;

Reference yield:

: 1363806-98-7
ethyl 2-(2,6-diethyl-4-methylphenyl)-2-oxoacetate

: 1363808-49-4
4-(2,6-diethyl-4-methylphenyl)-2,6-dimethyl-5-phenoxy-2,3-dihydro-3-pyridazinone

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydroxide; water / tetrahydrofuran / 3 h / 10 - 20 °C

2.1: thionyl chloride / N,N-dimethyl-formamide / toluene / 2 h / 50 °C / Inert atmosphere

3.1: triethylamine / toluene; acetonitrile / 2.5 h / 0 - 1 °C / Inert atmosphere

4.1: potassium carbonate / methanol / 3 h / Cooling with ice

5.1: sodium hydride / toluene; mineral oil / 0.08 h / 20 °C

5.2: 3 h / 20 - 100 °C

5.3: 1.5 h

With thionyl chloride; water; sodium hydride; potassium carbonate; triethylamine; sodium hydroxide; N,N-dimethyl-formamide; In tetrahydrofuran; methanol; toluene; acetonitrile; mineral oil;