ethyl 2-(5-chlorobenzo[d]thiazol-2-yl)acetate

Base Information

• Chemical Name: ethyl 2-(5-chlorobenzo[d]thiazol-2-yl)acetate
• CAS No.: 881634-13-5
• Molecular Formula: C₁₁H₁₀ClNO₂S
• Molecular Weight: 255.725
• Mol file: 881634-13-5.mol

Synonyms:ethyl 2-(5-chlorobenzo[d]thiazol-2-yl)acetate

Chemical Property of ethyl 2-(5-chlorobenzo[d]thiazol-2-yl)acetate

Chemical Property:

Purity/Quality:

98%min ^*data from raw suppliers

5-CHLORO-2-BENZOTHIAZOLEACETIC ACID ETHYL ESTER 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 2-(5-chlorobenzo[d]thiazol-2-yl)acetate

There total 1 articles about ethyl 2-(5-chlorobenzo[d]thiazol-2-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

ethyl 3-ethoxy-3-iminopropanoate hydrochloride (2318-25-4,165895-16-9) + 4-chloro-2-aminobenzenethiol (1004-00-8) → ethyl 2-(5-chlorobenzo[d]thiazol-2-yl)acetate (881634-13-5)

Guidance literature:

In ethanol; at 70 ℃; for 16h;

DOI:10.1021/acs.jmedchem.9b00147

Reference yield: 98.0%

ethyl 2-(5-chlorobenzo[d]thiazol-2-yl)acetate (881634-13-5) + 1-Phenyl-2-propen-1-ol (4393-06-0) → ethyl (E)-2-(5-chlorobenzo[d]thiazol-2-yl)-2-cinnamyl-5-phenylpent-4-enoate

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; diphenyl hydrogen phosphate; In dichloromethane; at 75 ℃; for 12h; chemoselective reaction; Sealed tube;

DOI:10.1002/adsc.201801351

Reference yield: 80.0%

phenylacetic anhydride (1555-80-2) + ethyl 2-(5-chlorobenzo[d]thiazol-2-yl)acetate (881634-13-5) + N,N-dimethyl-formamide dimethyl acetal (4637-24-5) → ethyl 8-chloro-1-oxo-2-phenyl-1H-pyrido[2,1-b][1,3]benzothiazole-4-carboxylate

Guidance literature:

at 110 ℃; for 2h; Green chemistry;

DOI:10.1016/j.ejmech.2020.112992

upstream raw materials:

ethyl 3-ethoxy-3-iminopropanoate hydrochloride

4-chloro-2-aminobenzenethiol

Refernces