(S)-2-amino-N-(4-methoxybenzyl)-3-phenylpropanamide hydrochloride

Base Information

• Chemical Name: (S)-2-amino-N-(4-methoxybenzyl)-3-phenylpropanamide hydrochloride
• CAS No.: 51537-65-6
• Molecular Formula: C₁₇H₂₀N₂O₂*ClH
• Molecular Weight: 320.819
• Mol file: 51537-65-6.mol

Synonyms:(S)-2-amino-N-(4-methoxybenzyl)-3-phenylpropanamide hydrochloride

Chemical Property of (S)-2-amino-N-(4-methoxybenzyl)-3-phenylpropanamide hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2-amino-N-(4-methoxybenzyl)-3-phenylpropanamide hydrochloride

There total 5 articles about (S)-2-amino-N-(4-methoxybenzyl)-3-phenylpropanamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

(S)-tert-butyl (1-((4-methoxybenzyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate (51537-64-5) → (S)-2-amino-N-(4-methoxybenzyl)-3-phenylpropanamide hydrochloride (51537-65-6)

Guidance literature:

With hydrogenchloride; In ethanol; dichloromethane; at 20 ℃; for 10h; Cooling with ice;

Reference yield:

N-tert-butoxycarbonyl-L-phenylalanine (13734-34-4) → (S)-2-amino-N-(4-methoxybenzyl)-3-phenylpropanamide hydrochloride (51537-65-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 81 percent / 1-ethyl-3-(3'-dimethylaminopropyl)carbodiimide hydrochloride; N-hydroxybenzotriazole*H₂O; triethylamine / CH₂Cl₂ / 24 h

2: 86 percent / HCl / dioxane; CH₂Cl₂ / 24 h

With hydrogenchloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In 1,4-dioxane; dichloromethane;

DOI:10.1016/j.bmcl.2004.06.018

Reference yield:

4-methoxy-benzylamine (2393-23-9) → (S)-2-amino-N-(4-methoxybenzyl)-3-phenylpropanamide hydrochloride (51537-65-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 81 percent / 1-ethyl-3-(3'-dimethylaminopropyl)carbodiimide hydrochloride; N-hydroxybenzotriazole*H₂O; triethylamine / CH₂Cl₂ / 24 h

2: 86 percent / HCl / dioxane; CH₂Cl₂ / 24 h

With hydrogenchloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In 1,4-dioxane; dichloromethane;

DOI:10.1016/j.bmcl.2004.06.018

upstream raw materials:

(S)-tert-butyl (1-((4-methoxybenzyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate

N-tert-butoxycarbonyl-L-phenylalanine

4-methoxy-benzylamine