C₁₉H₂₅N₃O₆

Base Information

• Chemical Name: C₁₉H₂₅N₃O₆
• CAS No.: 1204332-58-0
• Molecular Formula: C₁₉H₂₅N₃O₆
• Molecular Weight: 391.424
• Mol file: 1204332-58-0.mol

Synonyms:C₁₉H₂₅N₃O₆

Chemical Property of C₁₉H₂₅N₃O₆

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₉H₂₅N₃O₆

There total 6 articles about C₁₉H₂₅N₃O₆ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

allyl [(3R,6S)-4-benzyl-3-(tert-butoxycarbonylaminomethyl)-2,5-dioxopiperazin-6-yl]acetate (1342198-58-6) → C19H25N3O6 (1204332-58-0)

Guidance literature:

With pyrrolidine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triphenylphosphine; In dichloromethane; at 0 ℃; for 1h; Inert atmosphere;

DOI:10.1002/chem.201200457

Reference yield:

4-allyl 1-[(2R)-2-(benzylamino)-3-methoxy-3-oxopropyl] N-(tert-butoxycarbonyl)-L-aspartate (1258937-54-0) → C19H25N3O6 (1204332-58-0)

Guidance literature:

Multi-step reaction with 5 steps

1: dichloromethane / 2 h / 20 °C / Inert atmosphere

2: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 18 h / 20 °C / Inert atmosphere

3: hydrogen azide; di-isopropyl azodicarboxylate; triphenylphosphine / dichloromethane; toluene / 3.5 h / -20 °C / Inert atmosphere

4: trimethylphosphane / tetrahydrofuran / 5 h / -20 - 20 °C / Inert atmosphere

5: pyrrolidine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triphenylphosphine / dichloromethane / 1 h / 0 °C / Inert atmosphere

With pyrrolidine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; hydrogen azide; di-isopropyl azodicarboxylate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; trimethylphosphane; In tetrahydrofuran; dichloromethane; isopropyl alcohol; toluene; 3: Mitsunobu reaction;

DOI:10.1002/chem.201200457

Reference yield:

allyl [(2S,5R)-4-benzyl-5-(hydroxymethyl)-3,6-dioxopiperazin-2-yl]acetate (1258937-55-1) → C19H25N3O6 (1204332-58-0)

Guidance literature:

Multi-step reaction with 3 steps

1: hydrogen azide; di-isopropyl azodicarboxylate; triphenylphosphine / dichloromethane; toluene / 3.5 h / -20 °C / Inert atmosphere

2: trimethylphosphane / tetrahydrofuran / 5 h / -20 - 20 °C / Inert atmosphere

3: pyrrolidine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triphenylphosphine / dichloromethane / 1 h / 0 °C / Inert atmosphere

With pyrrolidine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; hydrogen azide; di-isopropyl azodicarboxylate; triphenylphosphine; trimethylphosphane; In tetrahydrofuran; dichloromethane; toluene; 1: Mitsunobu reaction;

DOI:10.1002/chem.201200457

upstream raw materials:

4-allyl 1-[(2R)-2-(benzylamino)-3-methoxy-3-oxopropyl] N-(tert-butoxycarbonyl)-L-aspartate

allyl [(2S,5R)-4-benzyl-5-(hydroxymethyl)-3,6-dioxopiperazin-2-yl]acetate

allyl [(3R,6S)-4-benzyl-3-(tert-butoxycarbonylaminomethyl)-2,5-dioxopiperazin-6-yl]acetate

methyl (2R)-2-(benzylamino)-3-hydroxypropanoate

Downstream raw materials:

C₃₈H₅₄N₈O₁₁S