2'-({[(S)-1-((R)-2-Benzyloxycarbonylamino-3,3-diphenyl-propionyl)-pyrrolidine-2-carbonyl]-amino}-methyl)-biphenyl-2-carboxylic acid

Base Information

• Chemical Name: 2'-({[(S)-1-((R)-2-Benzyloxycarbonylamino-3,3-diphenyl-propionyl)-pyrrolidine-2-carbonyl]-amino}-methyl)-biphenyl-2-carboxylic acid
• CAS No.: 195515-93-6
• Molecular Formula: C₄₂H₃₉N₃O₆
• Molecular Weight: 681.788
• Mol file: 195515-93-6.mol

Synonyms:2'-({[(S)-1-((R)-2-Benzyloxycarbonylamino-3,3-diphenyl-propionyl)-pyrrolidine-2-carbonyl]-amino}-methyl)-biphenyl-2-carboxylic acid

Chemical Property of 2'-({[(S)-1-((R)-2-Benzyloxycarbonylamino-3,3-diphenyl-propionyl)-pyrrolidine-2-carbonyl]-amino}-methyl)-biphenyl-2-carboxylic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2'-({[(S)-1-((R)-2-Benzyloxycarbonylamino-3,3-diphenyl-propionyl)-pyrrolidine-2-carbonyl]-amino}-methyl)-biphenyl-2-carboxylic acid

There total 1 articles about 2'-({[(S)-1-((R)-2-Benzyloxycarbonylamino-3,3-diphenyl-propionyl)-pyrrolidine-2-carbonyl]-amino}-methyl)-biphenyl-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

2'-aminomethylbiphenyl-2-carboxylic acid (31638-34-3) + (S)-1-((R)-2-Benzyloxycarbonylamino-3,3-diphenyl-propionyl)-pyrrolidine-2-carboxylic acid (138971-64-9) → 2'-({[(S)-1-((R)-2-Benzyloxycarbonylamino-3,3-diphenyl-propionyl)-pyrrolidine-2-carbonyl]-amino}-methyl)-biphenyl-2-carboxylic acid (195515-93-6)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane;

DOI:10.1016/S0960-894X(97)00371-5

Reference yield: 94.0%

2'-({[(S)-1-((R)-2-Benzyloxycarbonylamino-3,3-diphenyl-propionyl)-pyrrolidine-2-carbonyl]-amino}-methyl)-biphenyl-2-carboxylic acid (195515-93-6) → 2'-({[(S)-1-((R)-2-Amino-3,3-diphenyl-propionyl)-pyrrolidine-2-carbonyl]-amino}-methyl)-biphenyl-2-carboxylic acid (195515-94-7)

Guidance literature:

With hydrogen; palladium dihydroxide; In ethanol;

DOI:10.1016/S0960-894X(97)00371-5

Reference yield:

2'-({[(S)-1-((R)-2-Benzyloxycarbonylamino-3,3-diphenyl-propionyl)-pyrrolidine-2-carbonyl]-amino}-methyl)-biphenyl-2-carboxylic acid (195515-93-6) → C34H31N3O3

Guidance literature:

Multi-step reaction with 2 steps

1: 94 percent / H₂ / Pd(OH)2 / ethanol

2: 75 percent / PyBOP/DIEA / dimethylformamide; CH₂Cl₂

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; hydrogen; N-ethyl-N,N-diisopropylamine; palladium dihydroxide; In ethanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/S0960-894X(97)00371-5

upstream raw materials:

2'-aminomethylbiphenyl-2-carboxylic acid

(S)-1-((R)-2-Benzyloxycarbonylamino-3,3-diphenyl-propionyl)-pyrrolidine-2-carboxylic acid

Downstream raw materials:

2'-({[(S)-1-((R)-2-Amino-3,3-diphenyl-propionyl)-pyrrolidine-2-carbonyl]-amino}-methyl)-biphenyl-2-carboxylic acid