2-AMINOHEPTANE

Base Information

• Chemical Name: 2-AMINOHEPTANE
• CAS No.: 44652-67-7
• Molecular Formula: C₇H₁₇N
• Molecular Weight: 115.219
• Hs Code.: 2921199090
• Mol file: 44652-67-7.mol

Synonyms:2-Methylhexanamine

Chemical Property of 2-AMINOHEPTANE

Chemical Property:

• PSA: 26.02000
• LogP: 2.47170

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-AMINOHEPTANE

There total 4 articles about 2-AMINOHEPTANE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.8%

2-methylhexanonitrile (20654-42-6) → (+/-)-1-amino-2-methylhexane (44652-67-7)

Guidance literature:

2-methylhexanonitrile; With lithium aluminium tetrahydride; In diethyl ether; at 0 ℃; for 2h;

With sodium hydroxide; water; In diethyl ether;

Reference yield:

(+/-)-2-methylhexanamide (20923-63-1) → (+/-)-1-amino-2-methylhexane (44652-67-7)

Guidance literature:

With dimethylsulfide borane complex; In tetrahydrofuran; for 5h; Heating;

DOI:10.1016/S0040-4020(00)00189-7

Reference yield:

2-methylhexanoic acid (4536-23-6) → (+/-)-1-amino-2-methylhexane (44652-67-7)

Guidance literature:

Multi-step reaction with 3 steps

1: oxalyl chloride; DMF / CH₂Cl₂ / 1.5 h / 25 °C

2: 88 percent / aq. NH₃ / 0.5 h

3: BH₃*SMe₂ / tetrahydrofuran / 5 h / Heating

With ammonium hydroxide; oxalyl dichloride; dimethylsulfide borane complex; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane; 1: Substitution / 2: ammoniolysis / 3: Reduction;

DOI:10.1016/S0040-4020(00)00189-7

upstream raw materials:

(+/-)-2-methylhexanamide

2-methylhexanoic acid

2-methylhexanoyl chloride

2-methylhexanonitrile

Refernces

• 1、 Nicholas, Gillian M.,Molinski, Tadeusz F.. "Structures of cribochalines A and B, branched-chain methoxylaminoalkyl pyridines from the micronesian sponge, Cribochalina sp. absolute configuration and enantiomeric purity of related O-methyl oximes". . p. 2921 - 2927. Retrieved 2007/10/03.