20654-42-6Relevant academic research and scientific papers
Direct C(sp3)-H Cyanation Enabled by a Highly Active Decatungstate Photocatalyst
Kim, Kunsoon,Lee, Seulchan,Hong, Soon Hyeok
supporting information, p. 5501 - 5505 (2021/07/26)
A highly efficient, direct C(sp3)-H cyanation was developed under mild photocatalytic conditions. The method enabled the direct cyanation of various C(sp3)-H substrates with excellent functional group tolerance. Notably, complex natural products and bioactive compounds were efficiently cyanated.
MANUFACTURING METHOD OF NITRYL COMPOUND
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Paragraph 0051-0052, (2017/04/27)
PROBLEM TO BE SOLVED: To provide a method for manufacturing a nitryl compound at good efficiency and safety under a moderate reaction condition. SOLUTION: In a manufacturing method of a nitryl compound, an organic compound having a carbon-carbon unsaturated bond and acetone cyanhydrin are reacted in the presence of bivalent nickel compound, an organic phosphorus compound and a metal powder to add a nitryl group to one carbon constituting the carbon-carbon unsaturated bond. The metal powder is selected from zinc, magnesium, aluminum and manganese. The nickel compound is preferably halide salt of nickel, carboxylate of nickel and β-diketo compound salt of nickel. The organic phosphorus compound is preferably triphenylphosphine. The reaction between the organic compound and the acetone cyanhydrin can be conducted at a reaction temperature of 85°C to 90°C in a solvent of an alcohol compound. SELECTED DRAWING: None COPYRIGHT: (C)2017,JPOandINPIT
Efficient nickel-catalyzed hydrocyanation of alkenes using acetone cyanohydrin as a safer cyano source
Nemoto, Koji,Nagafuchi, Tsuyoshi,Tominaga, Ken-ichi,Sato, Kazuhiko
, p. 3199 - 3203 (2016/07/06)
An active nickel catalyst prepared in situ from a Ni(II) compound, phosphine ligand, and zinc powder was found to be an efficient catalyst system for the hydrocyanation of various alkenes using acetone cyanohydrin as a safer cyano source. The combination of NiCl2·6H2O and 1,3-bis(diphenylphosphino)propane was the most efficient catalyst precursor in DMF. Under the optimized conditions, various styrenes, heterocyclic alkenes, and aliphatic alkenes were converted to their corresponding nitriles in excellent yields.
The Novel Synthesis of Alkyl Cyanides by the Reaction of Sodium Trialkylcyanoborate with Sodium Cyanide and Lead(IV) Acetate
Masuda, Yuzuru,Hoshi, Masayuki,Yamada, Tetsuo,Arase, Akira
, p. 398 - 399 (2007/10/02)
Sodium trialkylcyanoborates gave good yields of the corresponding alkyl cyanides in the reaction with sodium cyanide and lead(IV) acetate.
