[2-[2-[2-Iodo-4-((S)-2-methyl-butoxy)-phenylethynyl]-4-((S)-2-methyl-butoxy)-phenylethynyl]-4-((S)-2-methyl-butoxy)-phenylethynyl]-trimethyl-silane

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Chemical Name:[2-[2-[2-Iodo-4-((S)-2-methyl-butoxy)-phenylethynyl]-4-((S)-2-methyl-butoxy)-phenylethynyl]-4-((S)-2-methyl-butoxy)-phenylethynyl]-trimethyl-silane
CAS No.:604800-47-7
Molecular Formula:C₄₂H₅₁IO₃Si
Molecular Weight:758.855
Hs Code.:

Synonyms:[2-[2-[2-Iodo-4-((S)-2-methyl-butoxy)-phenylethynyl]-4-((S)-2-methyl-butoxy)-phenylethynyl]-4-((S)-2-methyl-butoxy)-phenylethynyl]-trimethyl-silane

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Chemical Property of [2-[2-[2-Iodo-4-((S)-2-methyl-butoxy)-phenylethynyl]-4-((S)-2-methyl-butoxy)-phenylethynyl]-4-((S)-2-methyl-butoxy)-phenylethynyl]-trimethyl-silane

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Technology Process of [2-[2-[2-Iodo-4-((S)-2-methyl-butoxy)-phenylethynyl]-4-((S)-2-methyl-butoxy)-phenylethynyl]-4-((S)-2-methyl-butoxy)-phenylethynyl]-trimethyl-silane

There total 12 articles about [2-[2-[2-Iodo-4-((S)-2-methyl-butoxy)-phenylethynyl]-4-((S)-2-methyl-butoxy)-phenylethynyl]-4-((S)-2-methyl-butoxy)-phenylethynyl]-trimethyl-silane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: C₄₆H₆₁N₃O₃Si

: 604800-47-7
[2-[2-[2-Iodo-4-((S)-2-methyl-butoxy)-phenylethynyl]-4-((S)-2-methyl-butoxy)-phenylethynyl]-4-((S)-2-methyl-butoxy)-phenylethynyl]-trimethyl-silane

Guidance literature:: With methyl iodide; at 110 ℃; for 6h;
DOI:10.1021/ol0352254

Reference yield: 88.0%

: 604800-44-4
C₄₆H₆₁N₃O₃Si

: 604800-47-7
[2-[2-[2-Iodo-4-((S)-2-methyl-butoxy)-phenylethynyl]-4-((S)-2-methyl-butoxy)-phenylethynyl]-4-((S)-2-methyl-butoxy)-phenylethynyl]-trimethyl-silane

Guidance literature:: With methyl iodide; at 110 ℃; in sealed tube; Inert atmosphere;
DOI:10.1039/b9nj00200f

Reference yield:

: 1565-80-6
(2S)-2-methyl-1-butanol

: 604800-47-7
[2-[2-[2-Iodo-4-((S)-2-methyl-butoxy)-phenylethynyl]-4-((S)-2-methyl-butoxy)-phenylethynyl]-4-((S)-2-methyl-butoxy)-phenylethynyl]-trimethyl-silane

Guidance literature:: Multi-step reaction with 9 steps

1.1: 94 percent / PPh₃; DIAD / tetrahydrofuran / 0 - 20 °C

2.1: FeCl₃*6H₂O; N₂H₄*H₂O / carbon black / methanol / 2 h / 70 °C

3.1: HCl; NaNO₂ / acetonitrile; H₂O / 0.5 h / -5 - 0 °C

3.2: 65 percent / K₂CO₃ / acetonitrile; H₂O / 0.25 h / 20 °C

4.1: 90 percent / CuI; Et₃N / PdCl₂(PPh₃)2 / 12 h / 45 °C

5.1: 72 percent / CH₃I / 12 h / 110 °C

6.1: 65 percent / CuI; Et₃N / PdCl₂(PPh₃)2 / 12 h / 45 °C

7.1: 82 percent / K₂CO₃ / methanol; tetrahydrofuran / 20 °C

8.1: 60 percent / CuI; Et₃N / PdCl₂(PPh₃)2 / 45 °C

9.1: 88 percent / CH₃I / 6 h / 110 °C

With hydrogenchloride; copper(l) iodide; di-isopropyl azodicarboxylate; iron(III) chloride; potassium carbonate; hydrazine hydrate; triethylamine; triphenylphosphine; sodium nitrite; methyl iodide; bis-triphenylphosphine-palladium(II) chloride; pyrographite; In tetrahydrofuran; methanol; water; acetonitrile; 1.1: Mitsunobu reaction / 4.1: Sonogashira coupling reaction / 6.1: Sonogashira coupling reaction / 8.1: Sonogashira coupling reaction;
DOI:10.1021/ol0352254