Technology Process of 1-iodo-4-((S)-2-methyl-butoxy)-2-nitro-benzene
There total 1 articles about 1-iodo-4-((S)-2-methyl-butoxy)-2-nitro-benzene which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
di-isopropyl azodicarboxylate; triphenylphosphine;
In
tetrahydrofuran;
at 0 - 20 ℃;
DOI:10.1021/ol0352254
- Guidance literature:
-
With
iron(III) chloride hexahydrate; pyrographite; hydrazine;
In
methanol;
at 70 ℃;
DOI:10.1039/b9nj00200f
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: FeCl3*6H2O; N2H4*H2O / carbon black / methanol / 2 h / 70 °C
2.1: HCl; NaNO2 / acetonitrile; H2O / 0.5 h / -5 - 0 °C
2.2: 65 percent / K2CO3 / acetonitrile; H2O / 0.25 h / 20 °C
3.1: 90 percent / CuI; Et3N / PdCl2(PPh3)2 / 12 h / 45 °C
4.1: 72 percent / CH3I / 12 h / 110 °C
5.1: 65 percent / CuI; Et3N / PdCl2(PPh3)2 / 12 h / 45 °C
6.1: 82 percent / K2CO3 / methanol; tetrahydrofuran / 20 °C
7.1: 60 percent / CuI; Et3N / PdCl2(PPh3)2 / 45 °C
8.1: 88 percent / CH3I / 6 h / 110 °C
9.1: 52 percent / CuI; Et3N / PdCl2(PPh3)2 / 45 °C
With
hydrogenchloride; copper(l) iodide; iron(III) chloride; potassium carbonate; hydrazine hydrate; triethylamine; sodium nitrite; methyl iodide;
bis-triphenylphosphine-palladium(II) chloride; pyrographite;
In
tetrahydrofuran; methanol; water; acetonitrile;
3.1: Sonogashira coupling reaction / 5.1: Sonogashira coupling reaction / 7.1: Sonogashira coupling reaction / 9.1: Sonogashira coupling reaction;
DOI:10.1021/ol0352254
