tetraethyl 2-{4-[2-ethoxy-1-(ethoxycarbonyl)-2-oxoethyl]-3-nitrophenyl}propane-1,1,3,3-tetracarboxylate

Base Information

Chemical Name:tetraethyl 2-{4-[2-ethoxy-1-(ethoxycarbonyl)-2-oxoethyl]-3-nitrophenyl}propane-1,1,3,3-tetracarboxylate
CAS No.:1252576-44-5
Molecular Formula:C₂₈H₃₇NO₁₄
Molecular Weight:611.6
Hs Code.:

Synonyms:tetraethyl 2-{4-[2-ethoxy-1-(ethoxycarbonyl)-2-oxoethyl]-3-nitrophenyl}propane-1,1,3,3-tetracarboxylate

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Chemical Property of tetraethyl 2-{4-[2-ethoxy-1-(ethoxycarbonyl)-2-oxoethyl]-3-nitrophenyl}propane-1,1,3,3-tetracarboxylate

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Technology Process of tetraethyl 2-{4-[2-ethoxy-1-(ethoxycarbonyl)-2-oxoethyl]-3-nitrophenyl}propane-1,1,3,3-tetracarboxylate

There total 3 articles about tetraethyl 2-{4-[2-ethoxy-1-(ethoxycarbonyl)-2-oxoethyl]-3-nitrophenyl}propane-1,1,3,3-tetracarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 709-58-0
1-nitro-3-(trichloromethyl)benzene

: 105-53-3
diethyl malonate

: 1252576-44-5
tetraethyl 2-{4-[2-ethoxy-1-(ethoxycarbonyl)-2-oxoethyl]-3-nitrophenyl}propane-1,1,3,3-tetracarboxylate

Guidance literature:: With potassium tert-butylate; In tetrahydrofuran; N,N-dimethyl-formamide; at 0 ℃; for 3h; Inert atmosphere;
DOI:10.1002/ejoc.200901303

Reference yield: 23.0%

: 709-58-0
1-nitro-3-(trichloromethyl)benzene

: 105-53-3
diethyl malonate

: 1252576-39-8
diethyl [4-(dichloromethyl)-2-nitrophenyl]malonate

: 1252576-42-3
diethyl {4-[2-ethoxy-1-(ethoxycarbonyl)-2-oxoethyl]-3-nitrobenzylidene}malonate

: 1252576-44-5
tetraethyl 2-{4-[2-ethoxy-1-(ethoxycarbonyl)-2-oxoethyl]-3-nitrophenyl}propane-1,1,3,3-tetracarboxylate

Guidance literature:: With potassium tert-butylate; In tetrahydrofuran; N,N-dimethyl-formamide; at 0 ℃; for 3h; Inert atmosphere;
DOI:10.1002/ejoc.200901303

Reference yield: 14.0%

: 709-58-0
1-nitro-3-(trichloromethyl)benzene

: 105-53-3
diethyl malonate

: 1252576-42-3
diethyl {4-[2-ethoxy-1-(ethoxycarbonyl)-2-oxoethyl]-3-nitrobenzylidene}malonate

: (+/-)-tetraethyl 2,2'-[6-(dichloromethylene)-2-nitrocyclohex-4-ene-1,3-diyl]dimalonate

: 1252576-44-5
tetraethyl 2-{4-[2-ethoxy-1-(ethoxycarbonyl)-2-oxoethyl]-3-nitrophenyl}propane-1,1,3,3-tetracarboxylate

Guidance literature:: With potassium tert-butylate; In tetrahydrofuran; N,N-dimethyl-formamide; at -30 ℃; for 3h; diastereoselective reaction; Inert atmosphere;
DOI:10.1002/ejoc.200901303