4-amino-6-{4-[4-(4-fluoro-3-trifluoromethylphenyl)-1-methyl-1H-imidazol-2-yl]piperidin-1-yl}pyrimidine-5-carbaldehyde

Base Information

• Chemical Name: 4-amino-6-{4-[4-(4-fluoro-3-trifluoromethylphenyl)-1-methyl-1H-imidazol-2-yl]piperidin-1-yl}pyrimidine-5-carbaldehyde
• CAS No.: 1428248-74-1
• Molecular Formula: C₂₁H₂₀F₄N₆O
• Molecular Weight: 448.423

Synonyms:4-amino-6-{4-[4-(4-fluoro-3-trifluoromethylphenyl)-1-methyl-1H-imidazol-2-yl]piperidin-1-yl}pyrimidine-5-carbaldehyde

Chemical Property of 4-amino-6-{4-[4-(4-fluoro-3-trifluoromethylphenyl)-1-methyl-1H-imidazol-2-yl]piperidin-1-yl}pyrimidine-5-carbaldehyde

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Technology Process of 4-amino-6-{4-[4-(4-fluoro-3-trifluoromethylphenyl)-1-methyl-1H-imidazol-2-yl]piperidin-1-yl}pyrimidine-5-carbaldehyde

There total 1 articles about 4-amino-6-{4-[4-(4-fluoro-3-trifluoromethylphenyl)-1-methyl-1H-imidazol-2-yl]piperidin-1-yl}pyrimidine-5-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

6-(4-4-[4-fluoro-3-(trifluoromethyl)phenyl]-1-methyl-1H-imidazol-2-yl-piperidin-1-yl)pyrimidin-4-amine (1083051-56-2) + 4-amino-6-chloro-pyrimidine-5-carbaldehyde (14160-93-1) → 4-amino-6-{4-[4-(4-fluoro-3-trifluoromethylphenyl)-1-methyl-1H-imidazol-2-yl]piperidin-1-yl}pyrimidine-5-carbaldehyde (1428248-74-1)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 40 ℃; for 1h;

Reference yield: 72.0%

4-amino-6-{4-[4-(4-fluoro-3-trifluoromethylphenyl)-1-methyl-1H-imidazol-2-yl]piperidin-1-yl}pyrimidine-5-carbaldehyde (1428248-74-1) + methyl (triphenylphosphoranylidene)acetate (21204-67-1,2605-67-6) → (E)-3-(4-amino-6-{4-[4-(4-fluoro-3-trifluoromethylphenyl)-1-methyl-1H-imidazol-2-yl]piperidin-1-yl}pyrimidin-5-yl)acrylic acid methyl ester (1428249-13-1)

Guidance literature:

With triethylamine; lithium chloride; In dimethyl sulfoxide; at 60 ℃;

Reference yield: 65.0%

4-amino-6-{4-[4-(4-fluoro-3-trifluoromethylphenyl)-1-methyl-1H-imidazol-2-yl]piperidin-1-yl}pyrimidine-5-carbaldehyde (1428248-74-1) → (4-amino-6-{4-[4-(4-fluoro-3-trifluoromethylphenyl)-1-methyl-1H-imidazol-2-yl]piperidin-1-yl}pyrimidin-5-yl)methanol (1428249-04-0)

Guidance literature:

With sodium tetrahydroborate; ethanol; at 20 ℃;

upstream raw materials:

6-(4-4-[4-fluoro-3-(trifluoromethyl)phenyl]-1-methyl-1H-imidazol-2-yl-piperidin-1-yl)pyrimidin-4-amine

4-amino-6-chloro-pyrimidine-5-carbaldehyde

Downstream raw materials:

(E)-3-(4-amino-6-{4-[4-(4-fluoro-3-trifluoromethylphenyl)-1-methyl-1H-imidazol-2-yl]piperidin-1-yl}pyrimidin-5-yl)acrylic acid methyl ester

(4-amino-6-{4-[4-(4-fluoro-3-trifluoromethylphenyl)-1-methyl-1H-imidazol-2-yl]piperidin-1-yl}pyrimidin-5-yl)methanol

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