6-(4-4-[4-fluoro-3-(trifluoromethyl)phenyl]-1-methyl-1H-imidazol-2-yl-piperidin-1-yl)pyrimidin-4-amine

Base Information

Chemical Name:6-(4-4-[4-fluoro-3-(trifluoromethyl)phenyl]-1-methyl-1H-imidazol-2-yl-piperidin-1-yl)pyrimidin-4-amine
CAS No.:1083051-56-2
Molecular Formula:C₁₆H₁₇F₄N₃
Molecular Weight:327.325
Hs Code.:

Synonyms:6-(4-4-[4-fluoro-3-(trifluoromethyl)phenyl]-1-methyl-1H-imidazol-2-yl-piperidin-1-yl)pyrimidin-4-amine

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Chemical Property of 6-(4-4-[4-fluoro-3-(trifluoromethyl)phenyl]-1-methyl-1H-imidazol-2-yl-piperidin-1-yl)pyrimidin-4-amine

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Technology Process of 6-(4-4-[4-fluoro-3-(trifluoromethyl)phenyl]-1-methyl-1H-imidazol-2-yl-piperidin-1-yl)pyrimidin-4-amine

There total 10 articles about 6-(4-4-[4-fluoro-3-(trifluoromethyl)phenyl]-1-methyl-1H-imidazol-2-yl-piperidin-1-yl)pyrimidin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1082950-60-4
tert-butyl 4-(4-(4-fluoro-3-(trifluoromethyl)phenyl)-1-methyl-1H-imidazol-2-yl)piperidine-1-carboxylate

: 1083051-56-2
6-(4-4-[4-fluoro-3-(trifluoromethyl)phenyl]-1-methyl-1H-imidazol-2-yl-piperidin-1-yl)pyrimidin-4-amine

Guidance literature:: With ammonium acetate; acetic acid; In tetrahydrofuran; methanol; at 270 ℃; for 0.25h; Inert atmosphere;
DOI:10.1021/op200351g

Reference yield:

: 4-[4-(4-fluoro-3-trifluoromethyl-phenyl)-1-methyl-1H-imidazol-2-yl]-piperidine dihydrochloride

: 1083051-56-2
6-(4-4-[4-fluoro-3-(trifluoromethyl)phenyl]-1-methyl-1H-imidazol-2-yl-piperidin-1-yl)pyrimidin-4-amine

Guidance literature:: With triethylamine; In dimethyl sulfoxide; under 20 Torr;
DOI:10.1021/op200351g

Reference yield:

: 1370337-77-1
tert-butyl 4-((2-(4-fluoro-3-(trifluoromethyl)phenyl)-2-oxoethyl)(methyl)carbamoyl)piperidine-1-carboxylate

: 1083051-56-2
6-(4-4-[4-fluoro-3-(trifluoromethyl)phenyl]-1-methyl-1H-imidazol-2-yl-piperidin-1-yl)pyrimidin-4-amine

Guidance literature:: Multi-step reaction with 2 steps

1: ammonium acetate; acetic acid / methanol / 140 °C / Inert atmosphere; Large scale reaction

2: ammonium acetate; acetic acid / tetrahydrofuran; methanol / 0.25 h / 270 °C / Inert atmosphere

With ammonium acetate; acetic acid; In tetrahydrofuran; methanol;
DOI:10.1021/op200351g