Ethyl 2-amino-6-(4-methoxyphenyl)-3-pyridinecarboxylate

Base Information

Chemical Name:Ethyl 2-amino-6-(4-methoxyphenyl)-3-pyridinecarboxylate
CAS No.:70959-86-3
Molecular Formula:C₁₅H₁₆N₂O₃
Molecular Weight:272.304
Hs Code.:
DSSTox Substance ID:DTXSID601206532

Synonyms:Ethyl 2-amino-6-(4-methoxyphenyl)-3-pyridinecarboxylate;DTXSID601206532;70959-86-3

Suppliers and Price of Ethyl 2-amino-6-(4-methoxyphenyl)-3-pyridinecarboxylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Ethyl 2-amino-6-(4-methoxyphenyl)-3-pyridinecarboxylate

Chemical Property:

XLogP3:2.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:5
Exact Mass:272.11609238
Heavy Atom Count:20
Complexity:316

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CCOC(=O)C1=C(N=C(C=C1)C2=CC=C(C=C2)OC)N

Technology Process of Ethyl 2-amino-6-(4-methoxyphenyl)-3-pyridinecarboxylate

There total 6 articles about Ethyl 2-amino-6-(4-methoxyphenyl)-3-pyridinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 57508-48-2
carbethoxyacetamidine hydrochloride

: 16469-68-4
1-(4-methoxyphenyl)-2-propyn-1-one

: 70959-86-3
ethyl 2-amino-6-(4-methoxyphenyl)nicotinate

Guidance literature:: With sodium carbonate; In ethanol; at 150 ℃; for 1.5h; Microwave irradiation;
DOI:10.1055/s-0035-1561941

Reference yield: 69.0%

: 53019-97-9
(2Z,4Z)-2-Cyano-5-(4-methoxy-phenyl)-penta-2,4-dienoic acid ethyl ester

: 70959-86-3
ethyl 2-amino-6-(4-methoxyphenyl)nicotinate

Guidance literature:: With hydroxylamine; triethylamine; In water; N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1039/c2ob27053f

Reference yield:

: 1963-36-6
4-methoxycinnamaldehyde

: 105-56-6
ethyl 2-cyanoacetate

: 70959-86-3
ethyl 2-amino-6-(4-methoxyphenyl)nicotinate

Guidance literature:: Multi-step reaction with 2 steps

1: Alkaline conditions

2: hydroxylamine; triethylamine / N,N-dimethyl-formamide; water / 20 °C

With hydroxylamine; triethylamine; In water; N,N-dimethyl-formamide; 1: |Knoevenagel Condensation;
DOI:10.1039/c2ob27053f