16469-68-4

Basic information

• Product Name: 1-(4-methoxyphenyl)prop-2-yn-1-one
• Synonyms: 1-(4-Methoxyphenyl)-2-propyn-1-one; 2-propyn-1-one, 1-(4-methoxyphenyl)-
• CAS NO: 16469-68-4
• Molecular Formula: C₁₀H₈O₂
• Molecular Weight: 160.1693
• Mol File: 16469-68-4.mol
• Article Data: 38

Chemical Properties

• Boiling Point: 277.8°C at 760 mmHg
• Flash Point: 120.6°C
• Density: 1.102g/cm³
• Vapor Pressure: 0.00442mmHg at 25°C
• Refractive Index: 1.537
• CAS DataBase Reference: 1-(4-methoxyphenyl)prop-2-yn-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-methoxyphenyl)prop-2-yn-1-one(16469-68-4)
• EPA Substance Registry System: 1-(4-methoxyphenyl)prop-2-yn-1-one(16469-68-4)

Safety Data

• Hazardous Substances Data: 16469-68-4(Hazardous Substances Data)

Upstream product

• 99048-48-3 1‐(4‐methoxyphenyl)‐3‐(trimethylsilyl)prop‐2‐yn‐1‐one 
• 100-07-2 4-methoxy-benzoyl chloride 
• 1066-54-2 trimethylsilylacetylene 
• 123-11-5 4-methoxy-benzaldehyde 
• 52898-49-4 4,N-dimethoxy-N-methylbenzamide 
• 100-09-4 4-methoxybenzoic acid 
• 19115-30-1 1-(4-methoxyphenyl)-2-propyn-1-ol 
• 74-86-2 acetylene 

Downstream Products

• 10493-08-0 4',5,7-trimethoxyflavylium chloride 
• 15724-80-8 3-chloro-1-(4-methoxy-phenyl)-propenone 
• 22882-24-2 3-bromo-1-(4-methoxy-phenyl)-propenone 
• 144712-20-9 1-(4-methoxyphenyl)-2-(1,3-dithian-2-yl)ethan-1-one 
• 17113-31-4 2-(4-methoxyphenyl)furan 
• 62596-42-3 2-Ethyl-5-(4-methoxy-phenyl)-furan 
• 74714-13-9 (4-Methoxy-phenyl)-(6-methyl-4H-chromen-3-yl)-methanone 
• 74714-14-0 (1H-Benzo[f]chromen-2-yl)-(4-methoxy-phenyl)-methanone 
• 130042-86-3 2,5-dimethyl-3,4-diphenyl-benzophenone 
• 18476-67-0 2-(4-methoxyphenyl)-5-methylbenzofuran 
• 153865-95-3 5-(p-methoxybenzoylethynyl)-3',5'-di-O-(p-toluoyl)-2'-deoxyuridine 
• 115492-15-4 2,4-dimethoxy-5-<2-(p-methoxybenzoyl)ethynyl>pyrimidine 
• 73172-23-3 benzene-1,3,5-triyltris[(4-methoxyphenyl)methanone] 
• 16616-43-6 1-(4-methoxy-phenyl)-3-phenyl-propynone 

Relevant articles and documents

Mono-Gold(I)-Catalyzed Enantioselective Intermolecular Reaction of Ynones with Styrenes: Tandem Diels–Alder and Ene Sequence

Gold-catalyzed intermolecular reaction leading to dihydronaphthalene derivatives in one pot from two equivalents of ynones with respect to styrene is uncovered. The [4+2] Diels–Alder cycloaddition of ynones and styrenes is catalyzed by a mono-gold(I) complex and the conjugated acid to provide an unstable 3,8a-dihydronaphthalene to subsequently undergo an intermolecular ene-type reaction with the π-activated ynone to afford multi-component coupling dihydronaphthalene products. Linear relationships between chiral ligand-gold complexes and chiral dihydronaphthalene products proves mono-gold catalysis that triggers an asymmetric tandem Diels–Alder and ene reaction sequence.

Metabolically stable vanillin derivatives for the treatment of hypoxia

Vanillin derivative compounds that bind covalently with hemoglobin are provided. Methods of treating sickle cell disease and other hypoxia-related disorders by administering such compounds are also provided.

An investigation of structure‐activity relationships of azolylacryloyl derivatives yielded potent and long‐acting hemoglobin modulators for reversing erythrocyte sickling

Aromatic aldehydes that bind to sickle hemoglobin (HbS) to increase the protein oxygen affinity and/or directly inhibit HbS polymer formation to prevent the pathological hypoxia‐induced HbS polymerization and the subsequent erythrocyte sickling have for s