2-(S)-{[2-(4-diethylcarbamoyl-phenoxy)-4-(4-methoxy-phenoxy)-pyrimidin-5-ylamino]methyl}pyrrolidine-1-carboxylic acid tert-butyl ester

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Chemical Name:2-(S)-{[2-(4-diethylcarbamoyl-phenoxy)-4-(4-methoxy-phenoxy)-pyrimidin-5-ylamino]methyl}pyrrolidine-1-carboxylic acid tert-butyl ester
CAS No.:1297931-23-7
Molecular Formula:C₃₂H₄₁N₅O₆
Molecular Weight:591.707
Hs Code.:

Synonyms:2-(S)-{[2-(4-diethylcarbamoyl-phenoxy)-4-(4-methoxy-phenoxy)-pyrimidin-5-ylamino]methyl}pyrrolidine-1-carboxylic acid tert-butyl ester

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Chemical Property of 2-(S)-{[2-(4-diethylcarbamoyl-phenoxy)-4-(4-methoxy-phenoxy)-pyrimidin-5-ylamino]methyl}pyrrolidine-1-carboxylic acid tert-butyl ester

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Technology Process of 2-(S)-{[2-(4-diethylcarbamoyl-phenoxy)-4-(4-methoxy-phenoxy)-pyrimidin-5-ylamino]methyl}pyrrolidine-1-carboxylic acid tert-butyl ester

There total 6 articles about 2-(S)-{[2-(4-diethylcarbamoyl-phenoxy)-4-(4-methoxy-phenoxy)-pyrimidin-5-ylamino]methyl}pyrrolidine-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1297931-21-5
4-[5-Amino-4-(4-methoxy-phenoxy)-pyrimidin-2-yloxy]-N,N-diethyl-benzamide

: 69610-41-9,117625-90-8
Boc-L-Pro-H

: 1297931-23-7
2-(S)-{[2-(4-diethylcarbamoyl-phenoxy)-4-(4-methoxy-phenoxy)-pyrimidin-5-ylamino]methyl}pyrrolidine-1-carboxylic acid tert-butyl ester

Guidance literature:: With sodium cyanoborohydride; acetic acid; In methanol; at 20 ℃; for 4h;

Reference yield:

: 79119-31-6
N, N-diethyl-4-hydroxybenzamide

: 1297931-23-7
2-(S)-{[2-(4-diethylcarbamoyl-phenoxy)-4-(4-methoxy-phenoxy)-pyrimidin-5-ylamino]methyl}pyrrolidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydroxide / water; acetone / 20 h / 20 °C

2: hydrogen / palladium 10% on activated carbon / methanol / 20 h / 1654.92 Torr

3: sodium cyanoborohydride; acetic acid / methanol / 4 h / 20 °C

With hydrogen; sodium cyanoborohydride; acetic acid; sodium hydroxide; palladium 10% on activated carbon; In methanol; water; acetone;

Reference yield:

: 99-96-7
4-hydroxy-benzoic acid

: 1297931-23-7
2-(S)-{[2-(4-diethylcarbamoyl-phenoxy)-4-(4-methoxy-phenoxy)-pyrimidin-5-ylamino]methyl}pyrrolidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 20 h / 20 °C / Inert atmosphere

2: sodium hydroxide / water; acetone / 20 h / 20 °C

3: hydrogen / palladium 10% on activated carbon / methanol / 20 h / 1654.92 Torr

4: sodium cyanoborohydride; acetic acid / methanol / 4 h / 20 °C

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; hydrogen; sodium cyanoborohydride; benzotriazol-1-ol; acetic acid; N-ethyl-N,N-diisopropylamine; sodium hydroxide; palladium 10% on activated carbon; In methanol; water; N,N-dimethyl-formamide; acetone;