79119-31-6Relevant articles and documents
General Synthesis of Trialkyl-And Dialkylarylsilylboranes: Versatile Silicon Nucleophiles in Organic Synthesis
Shishido, Ryosuke,Uesugi, Minami,Takahashi, Rikuro,Mita, Tsuyoshi,Ishiyama, Tatsuo,Kubota, Koji,Ito, Hajime
supporting information, p. 14125 - 14133 (2020/09/16)
Compared to carbon-based nucleophiles, the number of silicon-based nucleophiles that is currently available remains limited, which significantly hampers the structural diversity of synthetically accessible silicon-based molecules. Given the high synthetic
A specific photosensitizer compound for a target cell.
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Paragraph 0043; 0044, (2017/08/23)
PROBLEM TO BE SOLVED: To provide a photosensitization compound which can apply oxidation stress selectively to a target cell, particularly a reporter enzyme expression cell such as β-galactosidase.SOLUTION: A selective photosensitization compound includes a compound represented by general formula (I) or salt thereof, where A represents a univalent group cut by an enzyme; R, R, R, R, R, and Rrepresent a hydrogen atom, a hydroxyl group or the like; and X represents a C-Calkylene group.
Synthesis and SAR of selective small molecule neuropeptide y Y2 receptor antagonists
Mittapalli, Gopi Kumar,Vellucci, Danielle,Yang, Jun,Toussaint, Marion,Brothers, Shaun P.,Wahlestedt, Claes,Roberts, Edward
scheme or table, p. 3916 - 3920 (2012/07/03)
Highly potent and selective small molecule neuropeptide Y Y2 receptor antagonists are reported. The systematic SAR exploration of a hit molecule N-(4-ethoxyphenyl)-4-[hydroxy(diphenyl)methyl]piperidine-1-carbothioamide, identified from HTS, led to the discovery of highly potent NPY Y2 antagonists 16 (CYM 9484) and 54 (CYM 9552) with IC50 values of 19 nM and 12 nM respectively.