(S)-N-(4-chlorobenzylidene)-2-methylpropane-2-sulfinamide

Base Information

• Chemical Name: (S)-N-(4-chlorobenzylidene)-2-methylpropane-2-sulfinamide
• CAS No.: 1207946-36-8
• Molecular Formula: C₁₁H₁₄ClNOS
• Molecular Weight: 243.757
• Mol file: 1207946-36-8.mol

Synonyms:(S)-N-(4-chlorobenzylidene)-2-methylpropane-2-sulfinamide

Chemical Property of (S)-N-(4-chlorobenzylidene)-2-methylpropane-2-sulfinamide

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of (S)-N-(4-chlorobenzylidene)-2-methylpropane-2-sulfinamide

There total 1 articles about (S)-N-(4-chlorobenzylidene)-2-methylpropane-2-sulfinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

4-chlorobenzaldehyde (104-88-1) + (S)-2-methylpropane-2-sulfinamide (343338-28-3) → (S)-N-(4-chlorobenzylidene)-2-methylpropane-2-sulfinamide (1207946-36-8)

Guidance literature:

With titanium(IV) tetraethanolate; In tetrahydrofuran;

DOI:10.1248/cpb.c110498

Reference yield: 99.0%

O,O'-diethyl thiophosphonate (999-01-9) + (S)-N-(4-chlorobenzylidene)-2-methylpropane-2-sulfinamide (1207946-36-8) → diethyl (S(S),R(C))-(-)-[(tert-butylsulfinylamino)(4-chlorophenyl)methyl]thiophosphonate (1207946-49-3)

Guidance literature:

With potassium carbonate; In dichloromethane; at 20 ℃; for 24h; optical yield given as %de; enantioselective reaction; Inert atmosphere;

DOI:10.1055/s-0029-1217054

Reference yield: 96.0%

3-chloro-2-fluoropropene (6186-91-0) + (S)-N-(4-chlorobenzylidene)-2-methylpropane-2-sulfinamide (1207946-36-8) → (S)-N-((R)-1-(4-chlorophenyl)-3-fluorobut-3-enyl)-2-methylpropane-2-sulfinamide (1582802-85-4)

Guidance literature:

With indium; In trans-1,2-dichloroethylene; at 53 ℃; for 48h; Solvent; Temperature; Concentration; Time; diastereoselective reaction; Inert atmosphere; Schlenk technique;

DOI:10.1021/jo402810s

upstream raw materials:

4-chlorobenzaldehyde

(S)-2-methylpropane-2-sulfinamide

Downstream raw materials:

ethyl 1',1'-diethoxyethyl-(S(S),R(C),S(P))-(+)-2-(tert-butylsulfinylamino)-2-(para-chlorophenyl)ethylphosphinate

ethyl 1',1'-diethoxyethyl-(S(S),R(C),R(P))-(-)-2-(tert-butylsulfinylamino)-2-(para-chlorophenyl)ethylphosphinate

diethyl (S(S),R(C))-(-)-[(tert-butylsulfinylamino)(4-chlorophenyl)methyl]thiophosphonate

C₁₇H₁₄ClF₅N₂O₄S