5-[4-(1-ethyl-1-{4-[5-(1-hydroxy-1-methylethyl)-furan-2-yl]-3-methyl-phenyl}-propyl)-2-methyl-phenoxy]-4(R)-hydroxy-pentanoic acid

Base Information

Chemical Name:5-[4-(1-ethyl-1-{4-[5-(1-hydroxy-1-methylethyl)-furan-2-yl]-3-methyl-phenyl}-propyl)-2-methyl-phenoxy]-4(R)-hydroxy-pentanoic acid
CAS No.:917022-82-3
Molecular Formula:C₃₁H₄₀O₆
Molecular Weight:508.655
Hs Code.:

Synonyms:5-[4-(1-ethyl-1-{4-[5-(1-hydroxy-1-methylethyl)-furan-2-yl]-3-methyl-phenyl}-propyl)-2-methyl-phenoxy]-4(R)-hydroxy-pentanoic acid

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Chemical Property of 5-[4-(1-ethyl-1-{4-[5-(1-hydroxy-1-methylethyl)-furan-2-yl]-3-methyl-phenyl}-propyl)-2-methyl-phenoxy]-4(R)-hydroxy-pentanoic acid

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Technology Process of 5-[4-(1-ethyl-1-{4-[5-(1-hydroxy-1-methylethyl)-furan-2-yl]-3-methyl-phenyl}-propyl)-2-methyl-phenoxy]-4(R)-hydroxy-pentanoic acid

There total 8 articles about 5-[4-(1-ethyl-1-{4-[5-(1-hydroxy-1-methylethyl)-furan-2-yl]-3-methyl-phenyl}-propyl)-2-methyl-phenoxy]-4(R)-hydroxy-pentanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.0%

: 917024-75-0
5(R)-[4-(1-ethyl-1-{4-[5-(1-hydroxy-1-methyl-ethyl)-furan-2-yl]-3-methyl-phenyl}-propyl)-2-methyl-phenoxymethyl]-dihydro-furan-2-one

: 917022-82-3
5-[4-(1-ethyl-1-{4-[5-(1-hydroxy-1-methylethyl)-furan-2-yl]-3-methyl-phenyl}-propyl)-2-methyl-phenoxy]-4(R)-hydroxy-pentanoic acid

Guidance literature:: With potassium hydroxide; water; In methanol; at 20 ℃; for 1h;

Reference yield:

: 2527-99-3
methyl 5-bromo-2-furoate

: 917022-82-3
5-[4-(1-ethyl-1-{4-[5-(1-hydroxy-1-methylethyl)-furan-2-yl]-3-methyl-phenyl}-propyl)-2-methyl-phenoxy]-4(R)-hydroxy-pentanoic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; toluene / 17 h / 85 °C

2.1: 1H-imidazole / N,N-dimethyl-formamide / 0.2 h / 20 °C

3.1: tetrahydrofuran / 3 h / 0 °C

4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.02 h / 20 °C

4.2: 11 h / 20 °C

5.1: potassium hydroxide; water / methanol / 1 h / 20 °C

With 1H-imidazole; potassium hydroxide; tetrabutyl ammonium fluoride; water; sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; toluene;

Reference yield:

: 865235-89-8
trifluoromethanesulfonic acid 4-[1-ethyl-1-(4-hydroxy-3-methylphenyl)-propyl]-2-methylphenyl ester

: 917022-82-3
5-[4-(1-ethyl-1-{4-[5-(1-hydroxy-1-methylethyl)-furan-2-yl]-3-methyl-phenyl}-propyl)-2-methyl-phenoxy]-4(R)-hydroxy-pentanoic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / dimethyl sulfoxide / 16 h / 80 °C

2.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; toluene / 17 h / 85 °C

3.1: 1H-imidazole / N,N-dimethyl-formamide / 0.2 h / 20 °C

4.1: tetrahydrofuran / 3 h / 0 °C

5.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.02 h / 20 °C

5.2: 11 h / 20 °C

6.1: potassium hydroxide; water / methanol / 1 h / 20 °C

With 1H-imidazole; potassium hydroxide; tetrabutyl ammonium fluoride; water; potassium acetate; sodium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; water; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;