2-fluorobenzyl 2-(3-((1-(2-fluorobenzyl)-6-oxo-1,6-dihydropyridazin-3-yl)methyl)-2-methyl-1H-indol-1-yl)acetate

Base Information

Chemical Name:2-fluorobenzyl 2-(3-((1-(2-fluorobenzyl)-6-oxo-1,6-dihydropyridazin-3-yl)methyl)-2-methyl-1H-indol-1-yl)acetate
CAS No.:1297284-32-2
Molecular Formula:C₃₀H₂₅F₂N₃O₃
Molecular Weight:513.544
Hs Code.:

Synonyms:2-fluorobenzyl 2-(3-((1-(2-fluorobenzyl)-6-oxo-1,6-dihydropyridazin-3-yl)methyl)-2-methyl-1H-indol-1-yl)acetate

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Chemical Property of 2-fluorobenzyl 2-(3-((1-(2-fluorobenzyl)-6-oxo-1,6-dihydropyridazin-3-yl)methyl)-2-methyl-1H-indol-1-yl)acetate

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Technology Process of 2-fluorobenzyl 2-(3-((1-(2-fluorobenzyl)-6-oxo-1,6-dihydropyridazin-3-yl)methyl)-2-methyl-1H-indol-1-yl)acetate

There total 8 articles about 2-fluorobenzyl 2-(3-((1-(2-fluorobenzyl)-6-oxo-1,6-dihydropyridazin-3-yl)methyl)-2-methyl-1H-indol-1-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 27.0%

: 446-48-0
o-fluorobenzyl bromide

: 1297284-31-1
2-(2-methyl-3-((6-oxo-1,6-dihydropyridazin-3-yl)methyl)-1H-indol-1-yl)-acetic acid

: 1297284-32-2
2-fluorobenzyl 2-(3-((1-(2-fluorobenzyl)-6-oxo-1,6-dihydropyridazin-3-yl)methyl)-2-methyl-1H-indol-1-yl)acetate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 85 ℃; for 16h; Inert atmosphere;

Reference yield:

: 13192-04-6
dimethyl 2-ketoglutarate

: 1297284-32-2
2-fluorobenzyl 2-(3-((1-(2-fluorobenzyl)-6-oxo-1,6-dihydropyridazin-3-yl)methyl)-2-methyl-1H-indol-1-yl)acetate

Guidance literature:: Multi-step reaction with 6 steps

1: hydrogenchloride / ethanol / 15 h / Inert atmosphere; Reflux

2: sodium tetrahydroborate; methanol / tetrahydrofuran / Reflux

3: manganese(IV) oxide / toluene / 20 h / Inert atmosphere; Reflux

4: trifluoroacetic acid; triethylsilane / dichloromethane / 24 h / 0 - 20 °C / Inert atmosphere

5: aluminum (III) chloride / toluene / 1 h / 140 °C / Microwave irradiation; Sealed with tube

6: potassium carbonate / N,N-dimethyl-formamide / 16 h / 85 °C / Inert atmosphere

With methanol; triethylsilane; manganese(IV) oxide; aluminum (III) chloride; sodium tetrahydroborate; potassium carbonate; trifluoroacetic acid; hydrogenchloride; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; toluene;

Reference yield:

: 95-20-5
2-methyl-1H-indole

: 1297284-32-2
2-fluorobenzyl 2-(3-((1-(2-fluorobenzyl)-6-oxo-1,6-dihydropyridazin-3-yl)methyl)-2-methyl-1H-indol-1-yl)acetate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 20 °C / Inert atmosphere

1.2: 16 h

2.1: trifluoroacetic acid; triethylsilane / dichloromethane / 24 h / 0 - 20 °C / Inert atmosphere

3.1: aluminum (III) chloride / toluene / 1 h / 140 °C / Microwave irradiation; Sealed with tube

4.1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 85 °C / Inert atmosphere

With triethylsilane; aluminum (III) chloride; sodium hydride; potassium carbonate; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide; toluene;