2-(3-((1-(2-fluorobenzyl)-6-oxo-1,6-dihydropyridazin-3-yl)methyl)-2-methyl-1H-indol-1-yl)acetic acid

Base Information

Chemical Name:2-(3-((1-(2-fluorobenzyl)-6-oxo-1,6-dihydropyridazin-3-yl)methyl)-2-methyl-1H-indol-1-yl)acetic acid
CAS No.:1297276-66-4
Molecular Formula:C₂₃H₂₀FN₃O₃
Molecular Weight:405.429
Hs Code.:

Synonyms:2-(3-((1-(2-fluorobenzyl)-6-oxo-1,6-dihydropyridazin-3-yl)methyl)-2-methyl-1H-indol-1-yl)acetic acid

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Chemical Property of 2-(3-((1-(2-fluorobenzyl)-6-oxo-1,6-dihydropyridazin-3-yl)methyl)-2-methyl-1H-indol-1-yl)acetic acid

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Technology Process of 2-(3-((1-(2-fluorobenzyl)-6-oxo-1,6-dihydropyridazin-3-yl)methyl)-2-methyl-1H-indol-1-yl)acetic acid

There total 9 articles about 2-(3-((1-(2-fluorobenzyl)-6-oxo-1,6-dihydropyridazin-3-yl)methyl)-2-methyl-1H-indol-1-yl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1297284-32-2
2-fluorobenzyl 2-(3-((1-(2-fluorobenzyl)-6-oxo-1,6-dihydropyridazin-3-yl)methyl)-2-methyl-1H-indol-1-yl)acetate

: 1297276-66-4
2-(3-((1-(2-fluorobenzyl)-6-oxo-1,6-dihydropyridazin-3-yl)methyl)-2-methyl-1H-indol-1-yl)acetic acid

Guidance literature:: 2-fluorobenzyl 2-(3-((1-(2-fluorobenzyl)-6-oxo-1,6-dihydropyridazin-3-yl)methyl)-2-methyl-1H-indol-1-yl)acetate; With sodium hydroxide; In methanol; at 20 ℃; for 16h; Inert atmosphere;

With hydrogenchloride; In methanol; water;

Reference yield:

: 13192-04-6
dimethyl 2-ketoglutarate

: 1297276-66-4
2-(3-((1-(2-fluorobenzyl)-6-oxo-1,6-dihydropyridazin-3-yl)methyl)-2-methyl-1H-indol-1-yl)acetic acid

Guidance literature:: Multi-step reaction with 7 steps

1: hydrogenchloride / ethanol / 15 h / Inert atmosphere; Reflux

2: sodium tetrahydroborate; methanol / tetrahydrofuran / Reflux

3: manganese(IV) oxide / toluene / 20 h / Inert atmosphere; Reflux

4: trifluoroacetic acid; triethylsilane / dichloromethane / 24 h / 0 - 20 °C / Inert atmosphere

5: aluminum (III) chloride / toluene / 1 h / 140 °C / Microwave irradiation; Sealed with tube

6: potassium carbonate / N,N-dimethyl-formamide / 16 h / 85 °C / Inert atmosphere

7: sodium hydroxide / methanol / 16 h / 20 °C / Inert atmosphere

With methanol; triethylsilane; manganese(IV) oxide; aluminum (III) chloride; sodium tetrahydroborate; potassium carbonate; trifluoroacetic acid; sodium hydroxide; hydrogenchloride; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1297284-31-1
2-(2-methyl-3-((6-oxo-1,6-dihydropyridazin-3-yl)methyl)-1H-indol-1-yl)-acetic acid

: 1297276-66-4
2-(3-((1-(2-fluorobenzyl)-6-oxo-1,6-dihydropyridazin-3-yl)methyl)-2-methyl-1H-indol-1-yl)acetic acid

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 85 °C / Inert atmosphere

2: sodium hydroxide / methanol / 16 h / 20 °C / Inert atmosphere

With potassium carbonate; sodium hydroxide; In methanol; N,N-dimethyl-formamide;