Carbonic acid 4-[(S)-2-((R)-4-((S)-2-benzyloxycarbonylamino-4-methyl-pentanoylamino)-1-{[((S)-1-carbamoyl-2-phenyl-ethylcarbamoyl)-methyl]-carbamoyl}-butylcarbamoyl)-2-tert-butoxycarbonylamino-ethyl]-phenyl ester tert-butyl ester

Base Information

• Chemical Name: Carbonic acid 4-[(S)-2-((R)-4-((S)-2-benzyloxycarbonylamino-4-methyl-pentanoylamino)-1-{[((S)-1-carbamoyl-2-phenyl-ethylcarbamoyl)-methyl]-carbamoyl}-butylcarbamoyl)-2-tert-butoxycarbonylamino-ethyl]-phenyl ester tert-butyl ester
• CAS No.: 210777-27-8
• Molecular Formula: C₄₉H₆₇N₇O₁₂
• Molecular Weight: 946.111

Synonyms:Carbonic acid 4-[(S)-2-((R)-4-((S)-2-benzyloxycarbonylamino-4-methyl-pentanoylamino)-1-{[((S)-1-carbamoyl-2-phenyl-ethylcarbamoyl)-methyl]-carbamoyl}-butylcarbamoyl)-2-tert-butoxycarbonylamino-ethyl]-phenyl ester tert-butyl ester

Chemical Property of Carbonic acid 4-[(S)-2-((R)-4-((S)-2-benzyloxycarbonylamino-4-methyl-pentanoylamino)-1-{[((S)-1-carbamoyl-2-phenyl-ethylcarbamoyl)-methyl]-carbamoyl}-butylcarbamoyl)-2-tert-butoxycarbonylamino-ethyl]-phenyl ester tert-butyl ester

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Technology Process of Carbonic acid 4-[(S)-2-((R)-4-((S)-2-benzyloxycarbonylamino-4-methyl-pentanoylamino)-1-{[((S)-1-carbamoyl-2-phenyl-ethylcarbamoyl)-methyl]-carbamoyl}-butylcarbamoyl)-2-tert-butoxycarbonylamino-ethyl]-phenyl ester tert-butyl ester

There total 3 articles about Carbonic acid 4-[(S)-2-((R)-4-((S)-2-benzyloxycarbonylamino-4-methyl-pentanoylamino)-1-{[((S)-1-carbamoyl-2-phenyl-ethylcarbamoyl)-methyl]-carbamoyl}-butylcarbamoyl)-2-tert-butoxycarbonylamino-ethyl]-phenyl ester tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-2-(2-{(R)-5-Benzyloxycarbonylamino-2-[(S)-2-tert-butoxycarbonylamino-3-(4-tert-butoxycarbonyloxy-phenyl)-propionylamino]-pentanoylamino}-acetylamino)-3-phenyl-propionic acid (210777-21-2) → Carbonic acid 4-[(S)-2-((R)-4-((S)-2-benzyloxycarbonylamino-4-methyl-pentanoylamino)-1-{[((S)-1-carbamoyl-2-phenyl-ethylcarbamoyl)-methyl]-carbamoyl}-butylcarbamoyl)-2-tert-butoxycarbonylamino-ethyl]-phenyl ester tert-butyl ester (210777-27-8)

Guidance literature:

Multi-step reaction with 3 steps

1: H₂ / Pd black / methanol; aq. acetic acid

2: DIEA / dimethylformamide

3: ammonium benzotriazol-1-olate, dicyclohexylcarbodiimide / dimethylformamide

With 1-hydroxy-1H-benzotriazole ammonium salt; hydrogen; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; palladium; In methanol; acetic acid; N,N-dimethyl-formamide;

DOI:10.1016/S0223-5234(98)80060-3

Reference yield:

(S)-2-(2-{(R)-5-((S)-2-Benzyloxycarbonylamino-4-methyl-pentanoylamino)-2-[(S)-2-tert-butoxycarbonylamino-3-(4-tert-butoxycarbonyloxy-phenyl)-propionylamino]-pentanoylamino}-acetylamino)-3-phenyl-propionic acid (210777-23-4) → Carbonic acid 4-[(S)-2-((R)-4-((S)-2-benzyloxycarbonylamino-4-methyl-pentanoylamino)-1-{[((S)-1-carbamoyl-2-phenyl-ethylcarbamoyl)-methyl]-carbamoyl}-butylcarbamoyl)-2-tert-butoxycarbonylamino-ethyl]-phenyl ester tert-butyl ester (210777-27-8)

Guidance literature:

With 1-hydroxy-1H-benzotriazole ammonium salt; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; Yield given;

DOI:10.1016/S0223-5234(98)80060-3

Reference yield:

(S)-2-(2-{(R)-5-Amino-2-[(S)-2-tert-butoxycarbonylamino-3-(4-tert-butoxycarbonyloxy-phenyl)-propionylamino]-pentanoylamino}-acetylamino)-3-phenyl-propionic acid (210777-41-6) → Carbonic acid 4-[(S)-2-((R)-4-((S)-2-benzyloxycarbonylamino-4-methyl-pentanoylamino)-1-{[((S)-1-carbamoyl-2-phenyl-ethylcarbamoyl)-methyl]-carbamoyl}-butylcarbamoyl)-2-tert-butoxycarbonylamino-ethyl]-phenyl ester tert-butyl ester (210777-27-8)

Guidance literature:

Multi-step reaction with 2 steps

1: DIEA / dimethylformamide

2: ammonium benzotriazol-1-olate, dicyclohexylcarbodiimide / dimethylformamide

With 1-hydroxy-1H-benzotriazole ammonium salt; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide;

DOI:10.1016/S0223-5234(98)80060-3

upstream raw materials:

(S)-2-(2-{(R)-5-((S)-2-Benzyloxycarbonylamino-4-methyl-pentanoylamino)-2-[(S)-2-tert-butoxycarbonylamino-3-(4-tert-butoxycarbonyloxy-phenyl)-propionylamino]-pentanoylamino}-acetylamino)-3-phenyl-propionic acid

(S)-2-(2-{(R)-5-Amino-2-[(S)-2-tert-butoxycarbonylamino-3-(4-tert-butoxycarbonyloxy-phenyl)-propionylamino]-pentanoylamino}-acetylamino)-3-phenyl-propionic acid

(S)-2-(2-{(R)-5-Benzyloxycarbonylamino-2-[(S)-2-tert-butoxycarbonylamino-3-(4-tert-butoxycarbonyloxy-phenyl)-propionylamino]-pentanoylamino}-acetylamino)-3-phenyl-propionic acid

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