4-ISOPROPOXY-PIPERIDINE

Base Information

• Chemical Name: 4-ISOPROPOXY-PIPERIDINE
• CAS No.: 43139-18-0
• Molecular Formula: C8H17 N O
• Molecular Weight: 143.229
• Hs Code.: 2933399090
• Mol file: 43139-18-0.mol

Synonyms:Piperidine,4-isopropoxy- (7CI); 4-Isopropoxypiperidine

Chemical Property of 4-ISOPROPOXY-PIPERIDINE

Chemical Property:

• Boiling Point: 184-186 °C
• PKA: 9.89±0.10(Predicted)
• PSA: 21.26000
• Density: 0.90±0.1 g/cm3(Predicted)
• LogP: 1.49220
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

4-Isopropoxypiperidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4-Isopropoxypiperidine was a useful reagent in the preparation of quinoline and isoquinoline derivatives as P2X7 antagonists useful in the treatment of P2X7 receptor associated diseases.

Technology Process of 4-ISOPROPOXY-PIPERIDINE

There total 3 articles about 4-ISOPROPOXY-PIPERIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

benzyl 4-isopropoxypiperidine-1-carboxylate (1614234-65-9) → 4-isopropoxypiperidine (43139-18-0)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In ethanol; ethyl acetate; under 1034.32 Torr;

DOI:10.1016/j.tet.2014.04.064

Reference yield:

benzyl 4-oxo-1-piperidinecarboxylate (19099-93-5) → 4-isopropoxypiperidine (43139-18-0)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylsilane; trimethylsilyl trifluoromethanesulfonate / dichloromethane / 0.5 h / -60 - 0 °C

2: hydrogen; palladium 10% on activated carbon / ethyl acetate; ethanol / 1034.32 Torr

With triethylsilane; trimethylsilyl trifluoromethanesulfonate; palladium 10% on activated carbon; hydrogen; In ethanol; dichloromethane; ethyl acetate;

DOI:10.1016/j.tet.2014.04.064

Reference yield:

→ 4-isopropoxypiperidine (43139-18-0)

Guidance literature:

aus 4-Isopropyloxy-pyridin, H2 in wss.Me.;

DOI:10.1007/BF00905909

upstream raw materials:

benzyl 4-oxo-1-piperidinecarboxylate

benzyl 4-isopropoxypiperidine-1-carboxylate