4-[N-(3-methylphenyl)amino]-7-[3-(4-morpholinyl)propoxy]-6-nitroquinazoline

Base Information

Chemical Name:4-[N-(3-methylphenyl)amino]-7-[3-(4-morpholinyl)propoxy]-6-nitroquinazoline
CAS No.:198961-79-4
Molecular Formula:C₂₂H₂₅N₅O₄
Molecular Weight:423.472
Hs Code.:

Synonyms:4-[N-(3-methylphenyl)amino]-7-[3-(4-morpholinyl)propoxy]-6-nitroquinazoline

Suppliers and Price of 4-[N-(3-methylphenyl)amino]-7-[3-(4-morpholinyl)propoxy]-6-nitroquinazoline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 4-[N-(3-methylphenyl)amino]-7-[3-(4-morpholinyl)propoxy]-6-nitroquinazoline

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 4-[N-(3-methylphenyl)amino]-7-[3-(4-morpholinyl)propoxy]-6-nitroquinazoline

There total 3 articles about 4-[N-(3-methylphenyl)amino]-7-[3-(4-morpholinyl)propoxy]-6-nitroquinazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 4441-30-9
3-morpholin-4-ylpropan-1-ol

: 162012-66-0
7-fluoro-4-[(3-methylphenyl)-amino]-6-nitroquinazoline

: 198961-79-4
4-[N-(3-methylphenyl)amino]-7-[3-(4-morpholinyl)propoxy]-6-nitroquinazoline

Guidance literature:: 3-morpholin-4-ylpropan-1-ol; With sodium; In tetrahydrofuran; at 20 ℃; for 2h;

7-fluoro-4-[(3-methylphenyl)-amino]-6-nitroquinazoline; In tetrahydrofuran; Further stages.;
DOI:10.1021/jm990482t

Reference yield:

: 108-44-1
1-amino-3-methylbenzene

: 198961-79-4
4-[N-(3-methylphenyl)amino]-7-[3-(4-morpholinyl)propoxy]-6-nitroquinazoline

Guidance literature:: Multi-step reaction with 2 steps

1.1: 88 percent / CH₂Cl₂; propan-2-ol / 0.5 h / 20 °C

2.1: Na / tetrahydrofuran / 2 h / 20 °C

2.2: 88 percent / tetrahydrofuran

With sodium; In tetrahydrofuran; dichloromethane; isopropyl alcohol; 1.1: Condensation / 2.1: deprotonation / 2.2: Substitution;
DOI:10.1021/jm990482t

Reference yield:

: 162012-70-6
4-chloro-7-fluoro-6-nitroquinazoline

: 198961-79-4
4-[N-(3-methylphenyl)amino]-7-[3-(4-morpholinyl)propoxy]-6-nitroquinazoline

Guidance literature:: Multi-step reaction with 2 steps

1.1: 88 percent / CH₂Cl₂; propan-2-ol / 0.5 h / 20 °C

2.1: Na / tetrahydrofuran / 2 h / 20 °C

2.2: 88 percent / tetrahydrofuran

With sodium; In tetrahydrofuran; dichloromethane; isopropyl alcohol; 1.1: Condensation / 2.1: deprotonation / 2.2: Substitution;
DOI:10.1021/jm990482t