2-hydroxy-4-hydroxymethyl-5-oxo-3-(1-phenylcarbonyloxypropyl)-2,5-dihydrofuran

Base Information

Chemical Name:2-hydroxy-4-hydroxymethyl-5-oxo-3-(1-phenylcarbonyloxypropyl)-2,5-dihydrofuran
CAS No.:229176-16-3
Molecular Formula:C₁₅H₁₆O₆
Molecular Weight:292.288
Hs Code.:

Synonyms:2-hydroxy-4-hydroxymethyl-5-oxo-3-(1-phenylcarbonyloxypropyl)-2,5-dihydrofuran

Suppliers and Price of 2-hydroxy-4-hydroxymethyl-5-oxo-3-(1-phenylcarbonyloxypropyl)-2,5-dihydrofuran

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2-hydroxy-4-hydroxymethyl-5-oxo-3-(1-phenylcarbonyloxypropyl)-2,5-dihydrofuran

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2-hydroxy-4-hydroxymethyl-5-oxo-3-(1-phenylcarbonyloxypropyl)-2,5-dihydrofuran

There total 6 articles about 2-hydroxy-4-hydroxymethyl-5-oxo-3-(1-phenylcarbonyloxypropyl)-2,5-dihydrofuran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 229176-15-2
5-ethoxy-4-hydroxymethyl-3-(1-phenylcarbonyloxypropyl)furan

: 229176-16-3
2-hydroxy-4-hydroxymethyl-5-oxo-3-(1-phenylcarbonyloxypropyl)-2,5-dihydrofuran

Guidance literature:: With hydrogenchloride; manganese(IV) oxide; In tetrahydrofuran; at -10 ℃; for 0.5h;
DOI:10.1016/S0040-4020(99)00191-X

Reference yield:

: 14092-31-0
1-ethyl-4-(tetrahydro-2-pyranyloxy)-2-butyn-1-ol

: 229176-16-3
2-hydroxy-4-hydroxymethyl-5-oxo-3-(1-phenylcarbonyloxypropyl)-2,5-dihydrofuran

Guidance literature:: Multi-step reaction with 6 steps

1: 88 percent / triethylamine; DMAP / tetrahydrofuran; CH₂Cl₂ / 1 h / 0 - 20 °C

2: 72 percent / PTSA / methanol / 3 h / 20 °C

3: 70 percent / PCC / CH₂Cl₂ / 3 h / 0 - 20 °C

4: 65 percent / toluene / 12 h / Heating

5: 82 percent / NaBH₄ / methanol / 1 h / 0 - 20 °C

6: 65 percent / conc. HCl; MnO₂ / tetrahydrofuran / 0.5 h / -10 °C

With hydrogenchloride; dmap; manganese(IV) oxide; sodium tetrahydroborate; toluene-4-sulfonic acid; triethylamine; pyridinium chlorochromate; In tetrahydrofuran; methanol; dichloromethane; toluene; 1: Esterification / 2: deprotection / 3: Oxidation / 4: Diels-Alder reaction / 5: Reduction / 6: Oxidation;
DOI:10.1016/S0040-4020(99)00191-X

Reference yield:

: 229176-13-0
1-ethyl-3-formyl-2-propynyl benzoate

: 229176-16-3
2-hydroxy-4-hydroxymethyl-5-oxo-3-(1-phenylcarbonyloxypropyl)-2,5-dihydrofuran

Guidance literature:: Multi-step reaction with 3 steps

1: 65 percent / toluene / 12 h / Heating

2: 82 percent / NaBH₄ / methanol / 1 h / 0 - 20 °C

3: 65 percent / conc. HCl; MnO₂ / tetrahydrofuran / 0.5 h / -10 °C

With hydrogenchloride; manganese(IV) oxide; sodium tetrahydroborate; In tetrahydrofuran; methanol; toluene; 1: Diels-Alder reaction / 2: Reduction / 3: Oxidation;
DOI:10.1016/S0040-4020(99)00191-X