1-(2-oxo-ethyl)-cyclopentanecarboxylic acid benzyl ester

Base Information

• Chemical Name: 1-(2-oxo-ethyl)-cyclopentanecarboxylic acid benzyl ester
• CAS No.: 1257266-84-4
• Molecular Formula: C₁₅H₁₈O₃
• Molecular Weight: 246.306
• Mol file: 1257266-84-4.mol

Synonyms:1-(2-oxo-ethyl)-cyclopentanecarboxylic acid benzyl ester

Chemical Property of 1-(2-oxo-ethyl)-cyclopentanecarboxylic acid benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 1-(2-oxo-ethyl)-cyclopentanecarboxylic acid benzyl ester

There total 5 articles about 1-(2-oxo-ethyl)-cyclopentanecarboxylic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

N-vinyl-N-methylacetamide (3195-78-6,26616-03-5) + benzyl 1-bromocyclopentane-1-carboxylate → 1-(2-oxo-ethyl)-cyclopentanecarboxylic acid benzyl ester (1257266-84-4)

Guidance literature:

With N,N,N',N'',N'''-pentamethyldiethylenetriamine; triethylamine; copper(ll) bromide; In tetrahydrofuran; water; at 60 ℃; for 20h; Inert atmosphere; Sealed tube;

DOI:10.1002/chem.201801065

Reference yield:

1-allyl-cyclopentanecarboxylic acid benzyl ester (378247-23-5) → 1-(2-oxo-ethyl)-cyclopentanecarboxylic acid benzyl ester (1257266-84-4)

Guidance literature:

1-allyl-cyclopentanecarboxylic acid benzyl ester; With ozone; In dichloromethane; for 0.5h;

In dichloromethane; at 20 ℃; for 5h;

Reference yield:

cyclopentanecarboxylic acid benzyl ester (78277-22-2) → 1-(2-oxo-ethyl)-cyclopentanecarboxylic acid benzyl ester (1257266-84-4)

Guidance literature:

Multi-step reaction with 2 steps

1: magnesium sulfate; diisopropylamine / hexane; tetrahydrofuran

2: dichloromethane

With magnesium sulfate; diisopropylamine; In tetrahydrofuran; hexane; dichloromethane;

upstream raw materials:

1-allyl-cyclopentanecarboxylic acid benzyl ester

benzyl bromide

cyclopentanecarboxylic acid

cyclopentanecarboxylic acid benzyl ester

Downstream raw materials:

1-carboxymethyl-cyclopentanecarboxylic acid benzyl ester