N-[3-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-b]pyridazin-6-yl}oxy)phenyl]-3-(1-hydroxy-1-methylethyl)benzamide

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Chemical Name:N-[3-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-b]pyridazin-6-yl}oxy)phenyl]-3-(1-hydroxy-1-methylethyl)benzamide
CAS No.:1005785-93-2
Molecular Formula:C₂₆H₂₅N₅O₄
Molecular Weight:471.516
Hs Code.:

Synonyms:N-[3-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-b]pyridazin-6-yl}oxy)phenyl]-3-(1-hydroxy-1-methylethyl)benzamide

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Chemical Property of N-[3-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-b]pyridazin-6-yl}oxy)phenyl]-3-(1-hydroxy-1-methylethyl)benzamide

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Technology Process of N-[3-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-b]pyridazin-6-yl}oxy)phenyl]-3-(1-hydroxy-1-methylethyl)benzamide

There total 5 articles about N-[3-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-b]pyridazin-6-yl}oxy)phenyl]-3-(1-hydroxy-1-methylethyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 19.0%

: 1005785-91-0
methyl 3-({[3-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-b]pyridazin-6-yl}oxy)phenyl]amino}carbonyl)benzoate

: 1005785-93-2
N-[3-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-b]pyridazin-6-yl}oxy)phenyl]-3-(1-hydroxy-1-methylethyl)benzamide

Guidance literature:: With hydrogenchloride; methylmagnesium bromide; In tetrahydrofuran; hexane; water; toluene;

Reference yield: 19.0%

: 1005785-91-0
methyl 3-({[3-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-b]pyridazin-6-yl}oxy)phenyl]amino}carbonyl)benzoate

: 75-16-1
methylmagnesium bromide

: 1005785-93-2
N-[3-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-b]pyridazin-6-yl}oxy)phenyl]-3-(1-hydroxy-1-methylethyl)benzamide

Guidance literature:: In tetrahydrofuran; toluene; at 20 ℃; for 12h; Cooling with ice;
DOI:10.1021/jm300126x

Reference yield:

: 1005785-69-2
ethyl (6-iodoimidazo[1,2-b]pyridazin-2-yl)carbamate

: 1005785-93-2
N-[3-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-b]pyridazin-6-yl}oxy)phenyl]-3-(1-hydroxy-1-methylethyl)benzamide

Guidance literature:: Multi-step reaction with 5 steps

1: barium hydroxide octahydrate / 1-methyl-pyrrolidin-2-one / 12 h / 120 °C

2: N,N-dimethyl acetamide / 16 h / 4 - 20 °C

3: potassium carbonate / N,N-dimethyl-formamide / 24 h / 150 °C

4: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 14 h / 20 °C

5: tetrahydrofuran; toluene / 12 h / 20 °C / Cooling with ice

With barium hydroxide octahydrate; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; N,N-dimethyl acetamide; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm300126x