9-(3-(4-(3,5-difluorophenyl)-1H-1,2,3-triazol-1-yl)propyl)-1-methoxy-3-methyl-9H-carbazole

Base Information

Chemical Name:9-(3-(4-(3,5-difluorophenyl)-1H-1,2,3-triazol-1-yl)propyl)-1-methoxy-3-methyl-9H-carbazole
CAS No.:1430117-67-1
Molecular Formula:C₂₅H₂₂F₂N₄O
Molecular Weight:432.473
Hs Code.:

Synonyms:9-(3-(4-(3,5-difluorophenyl)-1H-1,2,3-triazol-1-yl)propyl)-1-methoxy-3-methyl-9H-carbazole

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Chemical Property of 9-(3-(4-(3,5-difluorophenyl)-1H-1,2,3-triazol-1-yl)propyl)-1-methoxy-3-methyl-9H-carbazole

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Technology Process of 9-(3-(4-(3,5-difluorophenyl)-1H-1,2,3-triazol-1-yl)propyl)-1-methoxy-3-methyl-9H-carbazole

There total 3 articles about 9-(3-(4-(3,5-difluorophenyl)-1H-1,2,3-triazol-1-yl)propyl)-1-methoxy-3-methyl-9H-carbazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 1430117-60-4
1-methoxy-3-methyl-9-(3-azido)-propyl-9H-carbazole

: 151361-87-4
1-ethynyl-3,5-difluorobenzene

: 1430117-67-1
9-(3-(4-(3,5-difluorophenyl)-1H-1,2,3-triazol-1-yl)propyl)-1-methoxy-3-methyl-9H-carbazole

Guidance literature:: With copper(ll) sulfate pentahydrate; sodium ascorbate; In water; tert-butyl alcohol; at 20 ℃; for 12h; Inert atmosphere;
DOI:10.1007/s12272-013-0100-z

Reference yield:

: 4532-33-6
1-methoxy-3-methylcarbazole

: 1430117-67-1
9-(3-(4-(3,5-difluorophenyl)-1H-1,2,3-triazol-1-yl)propyl)-1-methoxy-3-methyl-9H-carbazole

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydride / tetrahydrofuran / 72 h / 20 °C / Inert atmosphere

2: sodium azide / acetonitrile / 72 h / Reflux

3: sodium ascorbate; copper(ll) sulfate pentahydrate / water; tert-butyl alcohol / 12 h / 20 °C / Inert atmosphere

With sodium azide; copper(ll) sulfate pentahydrate; sodium ascorbate; sodium hydride; In tetrahydrofuran; water; acetonitrile; tert-butyl alcohol; 3: |Huisgen Cycloaddition;
DOI:10.1007/s12272-013-0100-z

Reference yield:

: 1430117-58-0
1-methoxy-3-methyl-9-(3-bromo)-propyl-9H-carbazole

: 1430117-67-1
9-(3-(4-(3,5-difluorophenyl)-1H-1,2,3-triazol-1-yl)propyl)-1-methoxy-3-methyl-9H-carbazole

Guidance literature:: Multi-step reaction with 2 steps

1: sodium azide / acetonitrile / 72 h / Reflux

2: sodium ascorbate; copper(ll) sulfate pentahydrate / water; tert-butyl alcohol / 12 h / 20 °C / Inert atmosphere

With sodium azide; copper(ll) sulfate pentahydrate; sodium ascorbate; In water; acetonitrile; tert-butyl alcohol; 2: |Huisgen Cycloaddition;
DOI:10.1007/s12272-013-0100-z