METHYL-D3 CHLOROFORMATE

Base Information

• Chemical Name: METHYL-D3 CHLOROFORMATE
• CAS No.: 43049-56-5
• Molecular Formula: C2Cl D3 O2
• Molecular Weight: 97.515505334
• Mol file: 43049-56-5.mol

Synonyms:Methyl-d3chloroformate

Chemical Property of METHYL-D3 CHLOROFORMATE

Chemical Property:

• PSA: 26.30000
• LogP: 0.99160
• Storage Temp.: Refrigerator, under inert atmosphere
• Solubility.: Chloroform

Purity/Quality:

99% ^*data from raw suppliers

Methyl-d3 Chloroformate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Methyl-d3 Chloroformate is the isotope labelled analog of Chloroformic Acid Methyl Ester (C366740); a useful synthetic intemediate in the synthesis of a new class of potent Cdk4 inhibitors in the treatment of cancer. Also used in the synthesis of Phorboxazole B.

Technology Process of METHYL-D3 CHLOROFORMATE

There total 4 articles about METHYL-D3 CHLOROFORMATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

d(4)-methanol (811-98-3) + bis(trichloromethyl) carbonate (32315-10-9) → <(2)H3>methyl chloroformate (43049-56-5)

Guidance literature:

With pyridine; In dichloromethane; d⁽⁴⁾-methanol; at 0 ℃; for 3h;

Reference yield:

1,1,1-trideuteromethanol (1849-29-2) + bis(trichloromethyl) carbonate (32315-10-9) → <(2)H3>methyl chloroformate (43049-56-5)

Guidance literature:

With triethylamine; In toluene; at 0 - 20 ℃; for 2h;

Reference yield:

phosgene (75-44-5) + 1,1,1-trideuteromethanol (1849-29-2) → <(2)H3>methyl chloroformate (43049-56-5)

Guidance literature:

DOI:10.1016/0022-2860(90)80487-5

upstream raw materials:

phosgene

1,1,1-trideuteromethanol

d⁽⁴⁾-methanol

bis(trichloromethyl) carbonate

Downstream raw materials:

(S)-2-(d3-methoxy-carbonylamino)-3,3-d9-dimethylbutanoic acid

N-([3H₃]-methoxycarbonyl)-L-tert-leucine

7-methoxycarbonyl-3,5-dimethyl-4-oxo-1,2-diphenyl-6-trideuteriomethoxycarbonyl-6,7-diazabicyclo<3.2.0>hept-2-ene

Refernces

• 1、 Beak et al.. "". . p. 6027,6028,6032. Retrieved 1973.
• 2、 -. "Preparation method of deuterated daclatasvir intermediate". Paragraph 0056-0059. . Retrieved 2021/06/13.
• 3、 -. "Diarylpyrazole compound, composition containing the same and application thereof". Paragraph 0206; 0209; 0210; 0211. . Retrieved 2019/10/04.