C₃₇H₄₅N₃O₈

Base Information

Chemical Name:C₃₇H₄₅N₃O₈
CAS No.:1338594-58-3
Molecular Formula:C₃₇H₄₅N₃O₈
Molecular Weight:659.78
Hs Code.:

C<sub>37</sub>H<sub>45</sub>N<sub>3</sub>O<sub>8</sub>

Synonyms:C₃₇H₄₅N₃O₈

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Chemical Property of C₃₇H₄₅N₃O₈

Chemical Property:

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Technology Process of C₃₇H₄₅N₃O₈

There total 23 articles about C₃₇H₄₅N₃O₈ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: C₅₇H₆₇N₃O₁₁

: 1338594-58-3
C₃₇H₄₅N₃O₈

Guidance literature:: With methyl-phenyl-thioether; trifluoroacetic acid; In dichloromethane; at 0 ℃; for 1h;
DOI:10.1021/ol202528k

Reference yield:

: 154714-19-9
5-hydroxy-2,2-dimethyl-4H-benzo[d][1,3]dioxin-4-one

: 1338594-58-3
C₃₇H₄₅N₃O₈

Guidance literature:: Multi-step reaction with 14 steps

1.1: pyridine / dichloromethane

2.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; triethylamine / propan-1-ol

3.1: potassium hydroxide

4.1: di-isopropyl azodicarboxylate; triphenylphosphine / toluene / 20 °C / Inert atmosphere

5.1: potassium carbonate / acetone

6.1: Hoveyda-Grubbs catalyst second generation / dichloromethane / 4 h / 45 °C / Inert atmosphere

7.1: sodium hydroxide; trimethylphosphane / tetrahydrofuran; water / 4 h

8.1: dmap; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 1 h / 0 °C / Inert atmosphere

8.2: 48 h / 20 °C / Inert atmosphere

9.1: tetrabutyl ammonium fluoride / tetrahydrofuran

10.1: silver(l) oxide / dichloromethane / 0.25 h / Cooling with ice

10.2: 30 h / 20 °C

11.1: potassium hydroxide / ethanol

11.2: 1 h / 50 °C

12.1: sodium methylate / methanol / 40 °C

13.1: platinum(IV) oxide; hydrogen / tetrahydrofuran / 0 °C

14.1: methyl-phenyl-thioether; trifluoroacetic acid / dichloromethane / 1 h / 0 °C

With pyridine; dmap; platinum(IV) oxide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; Hoveyda-Grubbs catalyst second generation; methyl-phenyl-thioether; di-isopropyl azodicarboxylate; tetrabutyl ammonium fluoride; hydrogen; sodium methylate; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; triphenylphosphine; trifluoroacetic acid; potassium hydroxide; sodium hydroxide; silver(l) oxide; trimethylphosphane; In tetrahydrofuran; methanol; propan-1-ol; ethanol; dichloromethane; water; acetone; toluene; 4.1: Mitsunobu reaction;
DOI:10.1021/ol202528k

Reference yield:

: 2-Hydroxy-6-vinylbenzoic acid

: 1338594-58-3
C₃₇H₄₅N₃O₈

Guidance literature:: Multi-step reaction with 11 steps

1.1: di-isopropyl azodicarboxylate; triphenylphosphine / toluene / 20 °C / Inert atmosphere

2.1: potassium carbonate / acetone

3.1: Hoveyda-Grubbs catalyst second generation / dichloromethane / 4 h / 45 °C / Inert atmosphere

4.1: sodium hydroxide; trimethylphosphane / tetrahydrofuran; water / 4 h

5.1: dmap; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 1 h / 0 °C / Inert atmosphere

5.2: 48 h / 20 °C / Inert atmosphere

6.1: tetrabutyl ammonium fluoride / tetrahydrofuran

7.1: silver(l) oxide / dichloromethane / 0.25 h / Cooling with ice

7.2: 30 h / 20 °C

8.1: potassium hydroxide / ethanol

8.2: 1 h / 50 °C

9.1: sodium methylate / methanol / 40 °C

10.1: platinum(IV) oxide; hydrogen / tetrahydrofuran / 0 °C

11.1: methyl-phenyl-thioether; trifluoroacetic acid / dichloromethane / 1 h / 0 °C

With dmap; platinum(IV) oxide; Hoveyda-Grubbs catalyst second generation; methyl-phenyl-thioether; di-isopropyl azodicarboxylate; tetrabutyl ammonium fluoride; hydrogen; sodium methylate; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triphenylphosphine; trifluoroacetic acid; potassium hydroxide; sodium hydroxide; silver(l) oxide; trimethylphosphane; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; acetone; toluene; 1.1: Mitsunobu reaction;
DOI:10.1021/ol202528k