4-(benzoylamino)-1-[N-(1,3-dipivaloyloxyprop-2-yl)acetylaminomethyl]-1H-pyrimidin-2-one

Base Information

Chemical Name:4-(benzoylamino)-1-[N-(1,3-dipivaloyloxyprop-2-yl)acetylaminomethyl]-1H-pyrimidin-2-one
CAS No.:1257309-82-2
Molecular Formula:C₂₇H₃₆N₄O₇
Molecular Weight:528.605
Hs Code.:

Synonyms:4-(benzoylamino)-1-[N-(1,3-dipivaloyloxyprop-2-yl)acetylaminomethyl]-1H-pyrimidin-2-one

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Chemical Property of 4-(benzoylamino)-1-[N-(1,3-dipivaloyloxyprop-2-yl)acetylaminomethyl]-1H-pyrimidin-2-one

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Technology Process of 4-(benzoylamino)-1-[N-(1,3-dipivaloyloxyprop-2-yl)acetylaminomethyl]-1H-pyrimidin-2-one

There total 4 articles about 4-(benzoylamino)-1-[N-(1,3-dipivaloyloxyprop-2-yl)acetylaminomethyl]-1H-pyrimidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 26661-13-2
4-N-benzoylcytosine

: N-(1,3-dipivaloyloxyprop-2-yl)-N-(pivaloyloxymethyl)acetamide

: 1257309-82-2
4-(benzoylamino)-1-[N-(1,3-dipivaloyloxyprop-2-yl)acetylaminomethyl]-1H-pyrimidin-2-one

Guidance literature:: 4-N-benzoylcytosine; With N,O-bis-(trimethylsilyl)-acetamide; In acetonitrile; at 20 ℃; for 1h; Inert atmosphere;

N-(1,3-dipivaloyloxyprop-2-yl)-N-(pivaloyloxymethyl)acetamide; With trimethylsilyl trifluoromethanesulfonate; In acetonitrile; at 20 ℃; for 48h; Inert atmosphere;
DOI:10.1080/15257770.2010.519367

Reference yield:

: O,O'-dipivaloylserinol hydrochloride

: 1257309-82-2
4-(benzoylamino)-1-[N-(1,3-dipivaloyloxyprop-2-yl)acetylaminomethyl]-1H-pyrimidin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: pyridine / 24 h / 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 20 °C

2.2: 96 h / 20 °C / Cooling with ice

3.1: N,O-bis-(trimethylsilyl)-acetamide / acetonitrile / 1 h / 20 °C / Inert atmosphere

3.2: 48 h / 20 °C / Inert atmosphere

With pyridine; N,O-bis-(trimethylsilyl)-acetamide; sodium hydride; In N,N-dimethyl-formamide; acetonitrile; mineral oil;
DOI:10.1080/15257770.2010.519367

Reference yield:

: N-[1,3-bis(pivaloyloxy)prop-2-yl]acetamide

: 1257309-82-2
4-(benzoylamino)-1-[N-(1,3-dipivaloyloxyprop-2-yl)acetylaminomethyl]-1H-pyrimidin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 20 °C

1.2: 96 h / 20 °C / Cooling with ice

2.1: N,O-bis-(trimethylsilyl)-acetamide / acetonitrile / 1 h / 20 °C / Inert atmosphere

2.2: 48 h / 20 °C / Inert atmosphere

With N,O-bis-(trimethylsilyl)-acetamide; sodium hydride; In N,N-dimethyl-formamide; acetonitrile; mineral oil;
DOI:10.1080/15257770.2010.519367