(S)-methyl 2-((3S,6S)-4-((6S,9S,12S)-9-benzyl-6-(4-(tert-butoxy)benzyl)-12-(tert-butoxymethyl)-2,2-dimethyl-4,7,10-trioxo-3-oxa-5,8,11-triazatridecan-13-oyl)-6-(((tert-butyldiphenylsilyl)oxy)methyl)-3-isopropyl-2-oxopiperazin-1-yl)-3-(1H-indol-3-yl)propanoate

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Chemical Name:(S)-methyl 2-((3S,6S)-4-((6S,9S,12S)-9-benzyl-6-(4-(tert-butoxy)benzyl)-12-(tert-butoxymethyl)-2,2-dimethyl-4,7,10-trioxo-3-oxa-5,8,11-triazatridecan-13-oyl)-6-(((tert-butyldiphenylsilyl)oxy)methyl)-3-isopropyl-2-oxopiperazin-1-yl)-3-(1H-indol-3-yl)propanoate
CAS No.:1613043-89-2
Molecular Formula:C₇₀H₉₂N₆O₁₁Si
Molecular Weight:1221.62
Hs Code.:

(S)-methyl 2-((3S,6S)-4-((6S,9S,12S)-9-benzyl-6-(4-(tert-butoxy)benzyl)-12-(tert-butoxymethyl)-2,2-dimethyl-4,7,10-trioxo-3-oxa-5,8,11-triazatridecan-13-oyl)-6-(((tert-butyldiphenylsilyl)oxy)methyl)-3-isopropyl-2-oxopiperazin-1-yl)-3-(1H-indol-3-yl)propanoate

Synonyms:(S)-methyl 2-((3S,6S)-4-((6S,9S,12S)-9-benzyl-6-(4-(tert-butoxy)benzyl)-12-(tert-butoxymethyl)-2,2-dimethyl-4,7,10-trioxo-3-oxa-5,8,11-triazatridecan-13-oyl)-6-(((tert-butyldiphenylsilyl)oxy)methyl)-3-isopropyl-2-oxopiperazin-1-yl)-3-(1H-indol-3-yl)propanoate

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Chemical Property of (S)-methyl 2-((3S,6S)-4-((6S,9S,12S)-9-benzyl-6-(4-(tert-butoxy)benzyl)-12-(tert-butoxymethyl)-2,2-dimethyl-4,7,10-trioxo-3-oxa-5,8,11-triazatridecan-13-oyl)-6-(((tert-butyldiphenylsilyl)oxy)methyl)-3-isopropyl-2-oxopiperazin-1-yl)-3-(1H-indol-3-yl)propanoate

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Technology Process of (S)-methyl 2-((3S,6S)-4-((6S,9S,12S)-9-benzyl-6-(4-(tert-butoxy)benzyl)-12-(tert-butoxymethyl)-2,2-dimethyl-4,7,10-trioxo-3-oxa-5,8,11-triazatridecan-13-oyl)-6-(((tert-butyldiphenylsilyl)oxy)methyl)-3-isopropyl-2-oxopiperazin-1-yl)-3-(1H-indol-3-yl)propanoate

There total 5 articles about (S)-methyl 2-((3S,6S)-4-((6S,9S,12S)-9-benzyl-6-(4-(tert-butoxy)benzyl)-12-(tert-butoxymethyl)-2,2-dimethyl-4,7,10-trioxo-3-oxa-5,8,11-triazatridecan-13-oyl)-6-(((tert-butyldiphenylsilyl)oxy)methyl)-3-isopropyl-2-oxopiperazin-1-yl)-3-(1H-indol-3-yl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 1613044-01-1
Boc-Tyr(tBu)-Phe-OH

: (S)-methyl 2-((3S,6S)-4-((S)-2-amino-3-(tert-butoxy)propanoyl)-6-(((tert-butyldiphenyl-silyl)oxy)methyl)-3-isopropyl-2-oxopiperazin-1-yl)-3-(1H-indol-3-yl)propanoate

: 1613043-89-2
(S)-methyl 2-((3S,6S)-4-((6S,9S,12S)-9-benzyl-6-(4-(tert-butoxy)benzyl)-12-(tert-butoxymethyl)-2,2-dimethyl-4,7,10-trioxo-3-oxa-5,8,11-triazatridecan-13-oyl)-6-(((tert-butyldiphenylsilyl)oxy)methyl)-3-isopropyl-2-oxopiperazin-1-yl)-3-(1H-indol-3-yl)propanoate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In acetonitrile; at 20 ℃; for 18h;
DOI:10.1002/ejoc.201301773

Reference yield:

: 71989-33-8
Fmoc-Ser(tBu)-OH

: 1613043-89-2
(S)-methyl 2-((3S,6S)-4-((6S,9S,12S)-9-benzyl-6-(4-(tert-butoxy)benzyl)-12-(tert-butoxymethyl)-2,2-dimethyl-4,7,10-trioxo-3-oxa-5,8,11-triazatridecan-13-oyl)-6-(((tert-butyldiphenylsilyl)oxy)methyl)-3-isopropyl-2-oxopiperazin-1-yl)-3-(1H-indol-3-yl)propanoate

Guidance literature:: Multi-step reaction with 3 steps

1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 21 h / 40 °C

2: piperidine / N,N-dimethyl-formamide / 2 h / 20 °C

3: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / acetonitrile / 18 h / 20 °C

With piperidine; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; acetonitrile;
DOI:10.1002/ejoc.201301773

Reference yield:

: (S)-methyl 2-((3S,6S)-4-((S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-(tert-butoxy)propanoyl)-6-(((tert-butyldiphenylsilyl)oxy)methyl)-3-isopropyl-2-oxopiperazin-1-yl)-3-(1H-indol-3-yl)propanoate

: 1613043-89-2
(S)-methyl 2-((3S,6S)-4-((6S,9S,12S)-9-benzyl-6-(4-(tert-butoxy)benzyl)-12-(tert-butoxymethyl)-2,2-dimethyl-4,7,10-trioxo-3-oxa-5,8,11-triazatridecan-13-oyl)-6-(((tert-butyldiphenylsilyl)oxy)methyl)-3-isopropyl-2-oxopiperazin-1-yl)-3-(1H-indol-3-yl)propanoate

Guidance literature:: Multi-step reaction with 2 steps

1: piperidine / N,N-dimethyl-formamide / 2 h / 20 °C

2: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / acetonitrile / 18 h / 20 °C

With piperidine; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; acetonitrile;
DOI:10.1002/ejoc.201301773