5-{2,4-bis(benzyloxy)-5-[2-(4-fluoro-phenyl)-ethyl]-phenyl}-4-(4-formyl-phenyl)-isoxazole-3-carboxylic acid ethylamide

Base Information

Chemical Name:5-{2,4-bis(benzyloxy)-5-[2-(4-fluoro-phenyl)-ethyl]-phenyl}-4-(4-formyl-phenyl)-isoxazole-3-carboxylic acid ethylamide
CAS No.:1001385-79-0
Molecular Formula:C₄₁H₃₅FN₂O₅
Molecular Weight:654.738
Hs Code.:

Synonyms:5-{2,4-bis(benzyloxy)-5-[2-(4-fluoro-phenyl)-ethyl]-phenyl}-4-(4-formyl-phenyl)-isoxazole-3-carboxylic acid ethylamide

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Chemical Property of 5-{2,4-bis(benzyloxy)-5-[2-(4-fluoro-phenyl)-ethyl]-phenyl}-4-(4-formyl-phenyl)-isoxazole-3-carboxylic acid ethylamide

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Technology Process of 5-{2,4-bis(benzyloxy)-5-[2-(4-fluoro-phenyl)-ethyl]-phenyl}-4-(4-formyl-phenyl)-isoxazole-3-carboxylic acid ethylamide

There total 1 articles about 5-{2,4-bis(benzyloxy)-5-[2-(4-fluoro-phenyl)-ethyl]-phenyl}-4-(4-formyl-phenyl)-isoxazole-3-carboxylic acid ethylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 1001385-78-9
5-{2,4-bis(benzyloxy)-5-[2-(4-fluoro-phenyl)-ethyl]-phenyl}-4-bromoisoxazole-3-carboxylic acid ethylamide

: 87199-17-5
4-formylphenylboronic acid,

: 1001385-79-0
5-{2,4-bis(benzyloxy)-5-[2-(4-fluoro-phenyl)-ethyl]-phenyl}-4-(4-formyl-phenyl)-isoxazole-3-carboxylic acid ethylamide

Guidance literature:: With sodium hydrogencarbonate; bis-triphenylphosphine-palladium(II) chloride; In water; N,N-dimethyl-formamide; at 80 ℃; for 3.5h;
DOI:10.1021/jm701018h

Reference yield:

: 110-91-8,99108-56-2
morpholine

: 1001385-79-0
5-{2,4-bis(benzyloxy)-5-[2-(4-fluoro-phenyl)-ethyl]-phenyl}-4-(4-formyl-phenyl)-isoxazole-3-carboxylic acid ethylamide

: C₄₅H₄₄FN₃O₅

Guidance literature:: With 3 A molecular sieve; sodium cyanoborohydride; acetic acid; In dichloromethane; at 20 ℃; for 16h;
DOI:10.1021/jm701018h

Reference yield:

: 110-89-4
piperidine

: 1001385-79-0
5-{2,4-bis(benzyloxy)-5-[2-(4-fluoro-phenyl)-ethyl]-phenyl}-4-(4-formyl-phenyl)-isoxazole-3-carboxylic acid ethylamide

: C₄₆H₄₆FN₃O₄

Guidance literature:: With 3 A molecular sieve; sodium cyanoborohydride; acetic acid; In dichloromethane; at 20 ℃; for 16h;
DOI:10.1021/jm701018h