(4R,5R)-2-((R)-2-Benzyloxy-1,1-dimethyl-3-oxiranyl-propyl)-4,5-dimethyl-[1,3]dioxolane

Base Information

Chemical Name:(4R,5R)-2-((R)-2-Benzyloxy-1,1-dimethyl-3-oxiranyl-propyl)-4,5-dimethyl-[1,3]dioxolane
CAS No.:85708-39-0
Molecular Formula:C₁₉H₂₈O₄
Molecular Weight:320.429
Hs Code.:

Synonyms:(4R,5R)-2-((R)-2-Benzyloxy-1,1-dimethyl-3-oxiranyl-propyl)-4,5-dimethyl-[1,3]dioxolane

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Chemical Property of (4R,5R)-2-((R)-2-Benzyloxy-1,1-dimethyl-3-oxiranyl-propyl)-4,5-dimethyl-[1,3]dioxolane

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Technology Process of (4R,5R)-2-((R)-2-Benzyloxy-1,1-dimethyl-3-oxiranyl-propyl)-4,5-dimethyl-[1,3]dioxolane

There total 5 articles about (4R,5R)-2-((R)-2-Benzyloxy-1,1-dimethyl-3-oxiranyl-propyl)-4,5-dimethyl-[1,3]dioxolane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 73787-15-2
(4R,5R)-2-((R)-2-Benzyloxy-1,1-dimethyl-pent-4-enyl)-4,5-dimethyl-[1,3]dioxolane

: 85708-39-0
(4R,5R)-2-((R)-2-Benzyloxy-1,1-dimethyl-3-oxiranyl-propyl)-4,5-dimethyl-[1,3]dioxolane

Guidance literature:: With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; for 12h; Ambient temperature;
DOI:10.1016/0040-4020(84)80017-4

Reference yield:

: 597-31-9
2,2-dimethyl-3-hydroxypropionaldehyde

: 85708-39-0
(4R,5R)-2-((R)-2-Benzyloxy-1,1-dimethyl-3-oxiranyl-propyl)-4,5-dimethyl-[1,3]dioxolane

Guidance literature:: Multi-step reaction with 5 steps

1: p-TsOH*H₂O / benzene / 8 h / Heating

2: 64 percent / PCC, NaOAc / CH₂Cl₂ / 12 h / Ambient temperature

3: 2.) Jones reagent / 1.) ether, 12 h at r.t.; 2.) acetone, 30 min at 0 deg C

4: 1.) LiAlH₄; 2.) t-AmONa / 1.) ether, toluene, 2 h at -123 deg C; 2.) DMSO, 2 h at r.t.

5: 99 percent / mCPBA / CH₂Cl₂ / 12 h / Ambient temperature

With lithium aluminium tetrahydride; jones reagent; sodium acetate; sodium tert-pentoxide; toluene-4-sulfonic acid; 3-chloro-benzenecarboperoxoic acid; pyridinium chlorochromate; In dichloromethane; benzene;
DOI:10.1016/0040-4020(84)80017-4

Reference yield:

: 73787-13-0
2-((4R,5R)-4,5-Dimethyl-[1,3]dioxolan-2-yl)-2-methyl-hex-5-en-3-one

: 85708-39-0
(4R,5R)-2-((R)-2-Benzyloxy-1,1-dimethyl-3-oxiranyl-propyl)-4,5-dimethyl-[1,3]dioxolane

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) LiAlH₄; 2.) t-AmONa / 1.) ether, toluene, 2 h at -123 deg C; 2.) DMSO, 2 h at r.t.

2: 99 percent / mCPBA / CH₂Cl₂ / 12 h / Ambient temperature

With lithium aluminium tetrahydride; sodium tert-pentoxide; 3-chloro-benzenecarboperoxoic acid; In dichloromethane;
DOI:10.1016/0040-4020(84)80017-4