Technology Process of (4R,5R)-2-((2R,4S)-2-Benzyloxy-4,5-dimethoxy-1,1-dimethyl-pentyl)-4,5-dimethyl-[1,3]dioxolane
There total 9 articles about (4R,5R)-2-((2R,4S)-2-Benzyloxy-4,5-dimethoxy-1,1-dimethyl-pentyl)-4,5-dimethyl-[1,3]dioxolane which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 8 steps
1: p-TsOH*H2O / benzene / 8 h / Heating
2: 64 percent / PCC, NaOAc / CH2Cl2 / 12 h / Ambient temperature
3: 2.) Jones reagent / 1.) ether, 12 h at r.t.; 2.) acetone, 30 min at 0 deg C
4: 1.) LiAlH4; 2.) t-AmONa / 1.) ether, toluene, 2 h at -123 deg C; 2.) DMSO, 2 h at r.t.
5: 99 percent / mCPBA / CH2Cl2 / 12 h / Ambient temperature
6: 1.) NaOMe; 2.) Collins reagent / 1.) benzene, 2 d at r.t.; 2.) CH2Cl2, 2 h at r.t.
7: 95 percent / LiAlH(OtBu)3 / diethyl ether / 1 h / -78 °C
8: 93 percent / NaH / benzene / 2 h / Heating
With
lithium aluminium tetrahydride; jones reagent; Collins oxidation agent; sodium methylate; sodium acetate; sodium tert-pentoxide; sodium hydride; toluene-4-sulfonic acid; lithium tri-t-butoxyaluminum hydride; 3-chloro-benzenecarboperoxoic acid; pyridinium chlorochromate;
In
diethyl ether; dichloromethane; benzene;
DOI:10.1016/0040-4020(84)80017-4
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 1.) LiAlH4; 2.) t-AmONa / 1.) ether, toluene, 2 h at -123 deg C; 2.) DMSO, 2 h at r.t.
2: 99 percent / mCPBA / CH2Cl2 / 12 h / Ambient temperature
3: 1.) NaOMe; 2.) Collins reagent / 1.) benzene, 2 d at r.t.; 2.) CH2Cl2, 2 h at r.t.
4: 95 percent / LiAlH(OtBu)3 / diethyl ether / 1 h / -78 °C
5: 93 percent / NaH / benzene / 2 h / Heating
With
lithium aluminium tetrahydride; Collins oxidation agent; sodium methylate; sodium tert-pentoxide; sodium hydride; lithium tri-t-butoxyaluminum hydride; 3-chloro-benzenecarboperoxoic acid;
In
diethyl ether; dichloromethane; benzene;
DOI:10.1016/0040-4020(84)80017-4
![(2S,4R)-4-Benzyloxy-5-((4R,5R)-4,5-dimethyl-[1,3]dioxolan-2-yl)-1-methoxy-5-methyl-hexan-2-ol](/Databaselist/images/loading.webp)
