tert-butyl (3-fluoro-2-(((2-(tetrahydro-2H-thiopyran-4-yl)ethyl)amino)methyl)phenyl)carbamate

Base Information

Chemical Name:tert-butyl (3-fluoro-2-(((2-(tetrahydro-2H-thiopyran-4-yl)ethyl)amino)methyl)phenyl)carbamate
CAS No.:1605288-64-9
Molecular Formula:C₁₉H₂₉FN₂O₂S
Molecular Weight:368.516
Hs Code.:

Synonyms:tert-butyl (3-fluoro-2-(((2-(tetrahydro-2H-thiopyran-4-yl)ethyl)amino)methyl)phenyl)carbamate

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Chemical Property of tert-butyl (3-fluoro-2-(((2-(tetrahydro-2H-thiopyran-4-yl)ethyl)amino)methyl)phenyl)carbamate

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Technology Process of tert-butyl (3-fluoro-2-(((2-(tetrahydro-2H-thiopyran-4-yl)ethyl)amino)methyl)phenyl)carbamate

There total 1 articles about tert-butyl (3-fluoro-2-(((2-(tetrahydro-2H-thiopyran-4-yl)ethyl)amino)methyl)phenyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1262410-73-0
2-(tetrahydro-2H-thiopyran-4-yl)ethan-1-amine

: 1086392-03-1
tert-butyl (3-fluoro-2-formylphenyl)carbamate

: 1605288-64-9
tert-butyl (3-fluoro-2-(((2-(tetrahydro-2H-thiopyran-4-yl)ethyl)amino)methyl)phenyl)carbamate

Guidance literature:: 2-(tetrahydro-2H-thiopyran-4-yl)ethan-1-amine; tert-butyl (3-fluoro-2-formylphenyl)carbamate; With magnesium sulfate; In dichloromethane; at 20 ℃;

With sodium tetrahydroborate; In dichloromethane; for 16h;

Reference yield: 27.0%

: 129768-28-1
3-(trifluoromethyl)-1H-pyrazole-5-carboxylic acid

: 1605288-64-9
tert-butyl (3-fluoro-2-(((2-(tetrahydro-2H-thiopyran-4-yl)ethyl)amino)methyl)phenyl)carbamate

: 1605288-65-0
tert-butyl (3-fluoro-2-((N-(2-(tetrahydro-2H-thiopyran-4-yl)ethyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxamido)methyl)phenyl)carbamate

Guidance literature:: With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine; In ethyl acetate; acetonitrile; at 20 ℃; for 24h;

Reference yield:

: 1605288-64-9
tert-butyl (3-fluoro-2-(((2-(tetrahydro-2H-thiopyran-4-yl)ethyl)amino)methyl)phenyl)carbamate

: 1605288-67-2
tert-butyl (2-((N-(2-(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)ethyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxamido)methyl)-3-fluorophenyl)carbamate

Guidance literature:: Multi-step reaction with 2 steps

1: 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine / acetonitrile; ethyl acetate / 24 h / 20 °C

2: dihydrogen peroxide; ammonium molibdate / acetonitrile / 24 h / 20 °C

With ammonium molibdate; dihydrogen peroxide; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine; In ethyl acetate; acetonitrile;