1-(2-(4-[6-Hydroxy-2-(4-hydroxy-phenyl)-benzo[b]thiophene-3-carbonyl]-phenoxy)-ethyl)-piperidinium bromide

Base Information

• Chemical Name: 1-(2-(4-[6-Hydroxy-2-(4-hydroxy-phenyl)-benzo[b]thiophene-3-carbonyl]-phenoxy)-ethyl)-piperidinium bromide
• CAS No.: 1293408-87-3
• Molecular Formula: BrH*C₂₈H₂₇NO₄S
• Molecular Weight: 554.505
• Mol file: 1293408-87-3.mol

Synonyms:1-(2-(4-[6-Hydroxy-2-(4-hydroxy-phenyl)-benzo[b]thiophene-3-carbonyl]-phenoxy)-ethyl)-piperidinium bromide

Chemical Property of 1-(2-(4-[6-Hydroxy-2-(4-hydroxy-phenyl)-benzo[b]thiophene-3-carbonyl]-phenoxy)-ethyl)-piperidinium bromide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(2-(4-[6-Hydroxy-2-(4-hydroxy-phenyl)-benzo[b]thiophene-3-carbonyl]-phenoxy)-ethyl)-piperidinium bromide

There total 10 articles about 1-(2-(4-[6-Hydroxy-2-(4-hydroxy-phenyl)-benzo[b]thiophene-3-carbonyl]-phenoxy)-ethyl)-piperidinium bromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.4%

Raloxifen (84449-90-1) → 1-(2-(4-[6-Hydroxy-2-(4-hydroxy-phenyl)-benzo[b]thiophene-3-carbonyl]-phenoxy)-ethyl)-piperidinium bromide (1293408-87-3)

Guidance literature:

With hydrogen bromide; In methanol; water; at 1 - 35 ℃; pH=1.5; Reflux;

Reference yield: 80.4%

1-(2-{4-[6-Methoxy-2-(4-methoxy-phenyl)-benzo[b]thiophene-3-carbonyl]-phenoxy}-ethyl)-piperidinium bromide (1293362-54-5) → 1-(2-(4-[6-Hydroxy-2-(4-hydroxy-phenyl)-benzo[b]thiophene-3-carbonyl]-phenoxy)-ethyl)-piperidinium bromide (1293408-87-3)

Guidance literature:

With boron tribromide; In dichloromethane; at 15 - 39 ℃; for 3.5h; Product distribution / selectivity; Reflux;

Reference yield:

[6-Methoxy-2-(4-Methoxyphenyl)benzo[b]thien-3-yl]-[4-[2-(1-Piperidinyl)ethoxy]phenyl] Methanone (84541-38-8) → 1-(2-(4-[6-Hydroxy-2-(4-hydroxy-phenyl)-benzo[b]thiophene-3-carbonyl]-phenoxy)-ethyl)-piperidinium bromide (1293408-87-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: hydrogen bromide / methanol / 5 - 58 °C / pH 1

2.1: boron trichloride / dichloromethane / 2.5 h / 37 - 39 °C

2.2: 0.75 h / 17 - 32 °C / Reflux

With hydrogen bromide; boron trichloride; In methanol; dichloromethane;

upstream raw materials:

1-(2-{4-[6-Methoxy-2-(4-methoxy-phenyl)-benzo[b]thiophene-3-carbonyl]-phenoxy}-ethyl)-piperidinium bromide

Raloxifen

Ethyl 4-hydroxybenzoate

N-chloroethylpiperidine hydrochloride

Downstream raw materials:

Raloxifen

Refernces

• 1、 -. "A PROCESS FOR PREPARING BENZO[B]THIOPHENE DERIVATIVES". Page/Page column 71-73. . Retrieved 2011/05/06.