1-(2-{4-[6-Methoxy-2-(4-methoxy-phenyl)-benzo[b]thiophene-3-carbonyl]-phenoxy}-ethyl)-piperidinium bromide

Base Information

• Chemical Name: 1-(2-{4-[6-Methoxy-2-(4-methoxy-phenyl)-benzo[b]thiophene-3-carbonyl]-phenoxy}-ethyl)-piperidinium bromide
• CAS No.: 1293362-54-5
• Molecular Formula: BrH*C₃₀H₃₁NO₄S
• Molecular Weight: 582.558
• Mol file: 1293362-54-5.mol

Synonyms:1-(2-{4-[6-Methoxy-2-(4-methoxy-phenyl)-benzo[b]thiophene-3-carbonyl]-phenoxy}-ethyl)-piperidinium bromide

Chemical Property of 1-(2-{4-[6-Methoxy-2-(4-methoxy-phenyl)-benzo[b]thiophene-3-carbonyl]-phenoxy}-ethyl)-piperidinium bromide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(2-{4-[6-Methoxy-2-(4-methoxy-phenyl)-benzo[b]thiophene-3-carbonyl]-phenoxy}-ethyl)-piperidinium bromide

There total 9 articles about 1-(2-{4-[6-Methoxy-2-(4-methoxy-phenyl)-benzo[b]thiophene-3-carbonyl]-phenoxy}-ethyl)-piperidinium bromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.5%

[6-Methoxy-2-(4-Methoxyphenyl)benzo[b]thien-3-yl]-[4-[2-(1-Piperidinyl)ethoxy]phenyl] Methanone (84541-38-8) → 1-(2-{4-[6-Methoxy-2-(4-methoxy-phenyl)-benzo[b]thiophene-3-carbonyl]-phenoxy}-ethyl)-piperidinium bromide (1293362-54-5)

Guidance literature:

With hydrogen bromide; In methanol; water; at -6 - 58 ℃; pH=1; Product distribution / selectivity;

Reference yield: 77.2%

[2-(4-methoxyphenyl)-6-methoxybenzo[b]thien-3-yl][4-[2-(1-piperidinyl)ethoxy]phenyl]methanone hydrochloride (84541-36-6) → 1-(2-{4-[6-Methoxy-2-(4-methoxy-phenyl)-benzo[b]thiophene-3-carbonyl]-phenoxy}-ethyl)-piperidinium bromide (1293362-54-5)

Guidance literature:

[2-(4-methoxyphenyl)-6-methoxybenzo[b]thien-3-yl][4-[2-(1-piperidinyl)ethoxy]phenyl]methanone hydrochloride; With sodium hydroxide; In dichloromethane; water; at 18 ℃; for 0.25h;

With hydrogen bromide; In water; isopropyl alcohol; at 70 - 77 ℃; pH=1.5;

Reference yield:

Ethyl 4-hydroxybenzoate (120-47-8) → 1-(2-{4-[6-Methoxy-2-(4-methoxy-phenyl)-benzo[b]thiophene-3-carbonyl]-phenoxy}-ethyl)-piperidinium bromide (1293362-54-5)

Guidance literature:

Multi-step reaction with 7 steps

1.1: tetra(n-butyl)ammonium hydrogensulfate; potassium carbonate / ethyl acetate; water / 13 - 35 °C / Reflux

2.1: formic acid; sulfuric acid / acetic acid

3.1: thionyl chloride / N,N-dimethyl-formamide / toluene / 5 h / 65 - 70 °C

4.1: iron(III) sulfate pentahydrate; iron / toluene / 99 - 114 °C

4.2: 62 - 66 °C / Inert atmosphere

5.1: sodium hydroxide / tetrabutylammomium bromide / toluene; water / 6 h / Reflux

5.2: 20 °C

6.1: sodium hydroxide / dichloromethane; water / 6.75 h / 16 - 20 °C / Reflux

7.1: hydrogen bromide / methanol / 5 - 58 °C / pH 1

With formic acid; thionyl chloride; sulfuric acid; hydrogen bromide; tetra(n-butyl)ammonium hydrogensulfate; potassium carbonate; sodium hydroxide; iron(III) sulfate pentahydrate; tetrabutylammomium bromide; iron; N,N-dimethyl-formamide; In methanol; dichloromethane; water; acetic acid; ethyl acetate; toluene;

upstream raw materials:

[6-Methoxy-2-(4-Methoxyphenyl)benzo[b]thien-3-yl]-[4-[2-(1-Piperidinyl)ethoxy]phenyl] Methanone

[2-(4-methoxyphenyl)-6-methoxybenzo[b]thien-3-yl][4-[2-(1-piperidinyl)ethoxy]phenyl]methanone hydrochloride

Ethyl 4-hydroxybenzoate

N-chloroethylpiperidine hydrochloride

Downstream raw materials:

[2-(4-methoxyphenyl)-6-methoxybenzo[b]thien-3-yl][4-[2-(1-piperidinyl)ethoxy]phenyl]methanone hydrochloride

1-(2-(4-[6-Hydroxy-2-(4-hydroxy-phenyl)-benzo[b]thiophene-3-carbonyl]-phenoxy)-ethyl)-piperidinium bromide

Refernces

• 1、 -. "A process for preparing benzo[b]thiophene derivatives". Page/Page column 29. . Retrieved 2011/06/10.
• 2、 -. "A PROCESS FOR PREPARING BENZO[B]THIOPHENE DERIVATIVES". Page/Page column 63-64. . Retrieved 2011/05/06.