methyl 4-(6-nitro-4-(4-phenoxyphenylamino)quinazolin-2-ylamino)benzoate

Base Information

Chemical Name:methyl 4-(6-nitro-4-(4-phenoxyphenylamino)quinazolin-2-ylamino)benzoate
CAS No.:1308319-87-0
Molecular Formula:C₂₈H₂₁N₅O₅
Molecular Weight:507.505
Hs Code.:

Synonyms:methyl 4-(6-nitro-4-(4-phenoxyphenylamino)quinazolin-2-ylamino)benzoate

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Chemical Property of methyl 4-(6-nitro-4-(4-phenoxyphenylamino)quinazolin-2-ylamino)benzoate

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Technology Process of methyl 4-(6-nitro-4-(4-phenoxyphenylamino)quinazolin-2-ylamino)benzoate

There total 3 articles about methyl 4-(6-nitro-4-(4-phenoxyphenylamino)quinazolin-2-ylamino)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 1308319-80-3
2-chloro-6-nitro-N-(4-phenoxyphenyl)quinazolin-4-amine

: 619-45-4
4-methoxycarbonyl aniline

: 1308319-87-0
methyl 4-(6-nitro-4-(4-phenoxyphenylamino)quinazolin-2-ylamino)benzoate

Guidance literature:: With hydrogenchloride; In water; acetone; for 6.5h; Reflux;
DOI:10.1016/j.bmc.2011.03.058

Reference yield:

: 616-79-5
2-amino-5-nitro-benzoic acid

: 1308319-87-0
methyl 4-(6-nitro-4-(4-phenoxyphenylamino)quinazolin-2-ylamino)benzoate

Guidance literature:: Multi-step reaction with 4 steps

1: 10 h / 150 °C

2: phosphorus pentachloride; trichlorophosphate / 6.5 h / Reflux

3: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 8 h / 20 °C

4: hydrogenchloride / water; acetone / 6.5 h / Reflux

With hydrogenchloride; phosphorus pentachloride; N-ethyl-N,N-diisopropylamine; trichlorophosphate; In water; isopropyl alcohol; acetone;
DOI:10.1016/j.bmc.2011.03.058

Reference yield:

: 74173-77-6
2,4-dichloro-6-nitro-quinazoline

: 1308319-87-0
methyl 4-(6-nitro-4-(4-phenoxyphenylamino)quinazolin-2-ylamino)benzoate

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 8 h / 20 °C

2: hydrogenchloride / water; acetone / 6.5 h / Reflux

With hydrogenchloride; N-ethyl-N,N-diisopropylamine; In water; isopropyl alcohol; acetone;
DOI:10.1016/j.bmc.2011.03.058