(E)-N-[6-chloro-5-(2-methoxyphenoxy)-2-(pyrimidin-2-yl)pyrimidin-4-yl]-2-(4-methoxyphenyl)ethenesulfonamide

Base Information

• Chemical Name: (E)-N-[6-chloro-5-(2-methoxyphenoxy)-2-(pyrimidin-2-yl)pyrimidin-4-yl]-2-(4-methoxyphenyl)ethenesulfonamide
• CAS No.: 405262-77-3
• Molecular Formula: C₂₄H₂₀ClN₅O₅S
• Molecular Weight: 525.972

Synonyms:(E)-N-[6-chloro-5-(2-methoxyphenoxy)-2-(pyrimidin-2-yl)pyrimidin-4-yl]-2-(4-methoxyphenyl)ethenesulfonamide

Chemical Property of (E)-N-[6-chloro-5-(2-methoxyphenoxy)-2-(pyrimidin-2-yl)pyrimidin-4-yl]-2-(4-methoxyphenyl)ethenesulfonamide

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Technology Process of (E)-N-[6-chloro-5-(2-methoxyphenoxy)-2-(pyrimidin-2-yl)pyrimidin-4-yl]-2-(4-methoxyphenyl)ethenesulfonamide

There total 2 articles about (E)-N-[6-chloro-5-(2-methoxyphenoxy)-2-(pyrimidin-2-yl)pyrimidin-4-yl]-2-(4-methoxyphenyl)ethenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

4,6-dichloro-5-(2-methoxyphenoxy)-2,2'-bipyrimidine (150728-13-5) + (E)-2-(4-methoxyphenyl)ethenesulfonamide (206066-21-9) → (E)-N-[6-chloro-5-(2-methoxyphenoxy)-2-(pyrimidin-2-yl)pyrimidin-4-yl]-2-(4-methoxyphenyl)ethenesulfonamide (405262-77-3)

Guidance literature:

(E)-2-(4-methoxyphenyl)ethenesulfonamide; With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 0.166667h;

4,6-dichloro-5-(2-methoxyphenoxy)-2,2'-bipyrimidine; In N,N-dimethyl-formamide; at 20 ℃; for 2h;

DOI:10.1248/cpb.49.1593

Reference yield:

1-bromo-4-methoxy-benzene (104-92-7) → (E)-N-[6-chloro-5-(2-methoxyphenoxy)-2-(pyrimidin-2-yl)pyrimidin-4-yl]-2-(4-methoxyphenyl)ethenesulfonamide (405262-77-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 39 percent / PPh₃; Pd(OAc)2; Et₃N / dimethylformamide / 12 h / 130 °C

2.1: NaH / dimethylformamide / 0.17 h / 20 °C

2.2: 68 percent / dimethylformamide / 2 h / 20 °C

With palladium diacetate; sodium hydride; triethylamine; triphenylphosphine; In N,N-dimethyl-formamide; 1.1: Heck reaction;

DOI:10.1248/cpb.49.1593

Reference yield: 100.0%

sodium methylate (124-41-4) + (E)-N-[6-chloro-5-(2-methoxyphenoxy)-2-(pyrimidin-2-yl)pyrimidin-4-yl]-2-(4-methoxyphenyl)ethenesulfonamide (405262-77-3) → (E)-2-(4-Methoxy-phenyl)-ethenesulfonic acid [6-methoxy-5-(2-methoxy-phenoxy)-[2,2']bipyrimidinyl-4-yl]-amide

Guidance literature:

In methanol; at 20 ℃; for 2h;

DOI:10.1248/cpb.49.1593

upstream raw materials:

4,6-dichloro-5-(2-methoxyphenoxy)-2,2'-bipyrimidine

(E)-2-(4-methoxyphenyl)ethenesulfonamide

1-bromo-4-methoxy-benzene

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