1,7-di(carboxymethyl)-4,10-di(benzyloxycarbonyl)-1,4,7,10-tetraazacyclododecane

Base Information

• Chemical Name: 1,7-di(carboxymethyl)-4,10-di(benzyloxycarbonyl)-1,4,7,10-tetraazacyclododecane
• CAS No.: 325147-65-7
• Molecular Formula: C₂₈H₃₆N₄O₈
• Molecular Weight: 556.616
• Mol file: 325147-65-7.mol

Synonyms:1,7-di(carboxymethyl)-4,10-di(benzyloxycarbonyl)-1,4,7,10-tetraazacyclododecane

Chemical Property of 1,7-di(carboxymethyl)-4,10-di(benzyloxycarbonyl)-1,4,7,10-tetraazacyclododecane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,7-di(carboxymethyl)-4,10-di(benzyloxycarbonyl)-1,4,7,10-tetraazacyclododecane

There total 1 articles about 1,7-di(carboxymethyl)-4,10-di(benzyloxycarbonyl)-1,4,7,10-tetraazacyclododecane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

bromoacetic acid (79-08-3) + 1,4,7,10-tetraaza-cyclododecane-1,7-dicarboxylic acid dibenzyl ester (162148-45-0) → 1,7-di(carboxymethyl)-4,10-di(benzyloxycarbonyl)-1,4,7,10-tetraazacyclododecane (325147-65-7)

Guidance literature:

With potassium hydroxide; potassium carbonate; In methanol; at 45 - 65 ℃;

DOI:10.1021/jo000926p

Reference yield: 56.0%

thiazolidine-2-thione (134469-06-0) + 1,7-di(carboxymethyl)-4,10-di(benzyloxycarbonyl)-1,4,7,10-tetraazacyclododecane (325147-65-7) → 1,7-bis[2-oxo-2-(2-thioxo-1,3-thiazolidin-3-yl)ethyl]-4,10-di(benzyloxycarbonyl)-1,4,7,10-tetraazacyclododecane (260265-77-8)

Guidance literature:

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 0 - 20 ℃;

DOI:10.1021/jo000926p

Reference yield: 7.0%

(E)-4,4'-bis(3-aminopropoxy)azobenzene dihydrobromide + 1,7-di(carboxymethyl)-4,10-di(benzyloxycarbonyl)-1,4,7,10-tetraazacyclododecane (325147-65-7) → C46H56N8O8 (260265-79-0)

Guidance literature:

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; UV-irradiation;

DOI:10.1021/jo000926p

upstream raw materials:

bromoacetic acid

1,4,7,10-tetraaza-cyclododecane-1,7-dicarboxylic acid dibenzyl ester

Downstream raw materials:

1,7-bis[2-oxo-2-(2-thioxo-1,3-thiazolidin-3-yl)ethyl]-4,10-di(benzyloxycarbonyl)-1,4,7,10-tetraazacyclododecane

C₄₆H₅₆N₈O₈

C₄₄H₅₂N₈O₈

C₄₈H₆₀N₈O₈