5-{2-[4-(3-trifluoromethylphenyl)piperazin-1-yl]ethyl}-2-methylaminophenol

Base Information

Chemical Name:5-{2-[4-(3-trifluoromethylphenyl)piperazin-1-yl]ethyl}-2-methylaminophenol
CAS No.:206870-14-6
Molecular Formula:C₂₀H₂₄F₃N₃O
Molecular Weight:379.425
Hs Code.:

Synonyms:5-{2-[4-(3-trifluoromethylphenyl)piperazin-1-yl]ethyl}-2-methylaminophenol

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Chemical Property of 5-{2-[4-(3-trifluoromethylphenyl)piperazin-1-yl]ethyl}-2-methylaminophenol

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Technology Process of 5-{2-[4-(3-trifluoromethylphenyl)piperazin-1-yl]ethyl}-2-methylaminophenol

There total 3 articles about 5-{2-[4-(3-trifluoromethylphenyl)piperazin-1-yl]ethyl}-2-methylaminophenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 92532-71-3
3-Methyl-6-{2-[4-(3-trifluoromethyl-phenyl)-piperazin-1-yl]-ethyl}-3H-benzooxazol-2-one

: 206870-14-6
5-{2-[4-(3-trifluoromethylphenyl)piperazin-1-yl]ethyl}-2-methylaminophenol

Guidance literature:: With sodium hydroxide; In methanol; for 3h; Heating;
DOI:10.1021/jm970298c

Reference yield:

: 15532-75-9
1-(3-Trifluoromethylphenyl)piperazine

: 206870-14-6
5-{2-[4-(3-trifluoromethylphenyl)piperazin-1-yl]ethyl}-2-methylaminophenol

Guidance literature:: Multi-step reaction with 2 steps

1: 70 percent / Et₃N / acetone / 72 h / Heating

2: 59 percent / 10percent aq. NaOH / methanol / 3 h / Heating

With sodium hydroxide; triethylamine; In methanol; acetone;
DOI:10.1021/jm970298c

Reference yield:

: 92584-73-1
3-methyl-6-(2-bromoethyl)-benzoxazolinone

: 206870-14-6
5-{2-[4-(3-trifluoromethylphenyl)piperazin-1-yl]ethyl}-2-methylaminophenol

Guidance literature:: Multi-step reaction with 2 steps

1: 70 percent / Et₃N / acetone / 72 h / Heating

2: 59 percent / 10percent aq. NaOH / methanol / 3 h / Heating

With sodium hydroxide; triethylamine; In methanol; acetone;
DOI:10.1021/jm970298c