N-(2-Mercaptoethyl)-P-phenyl-P-(2-phthalimidoethyl)phosphinsaeureamid

Base Information

• Chemical Name: N-(2-Mercaptoethyl)-P-phenyl-P-(2-phthalimidoethyl)phosphinsaeureamid
• CAS No.: 160194-57-0
• Molecular Formula: C₁₈H₁₉N₂O₃PS
• Molecular Weight: 374.4
• Mol file: 160194-57-0.mol

Synonyms:N-(2-Mercaptoethyl)-P-phenyl-P-(2-phthalimidoethyl)phosphinsaeureamid

Chemical Property of N-(2-Mercaptoethyl)-P-phenyl-P-(2-phthalimidoethyl)phosphinsaeureamid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(2-Mercaptoethyl)-P-phenyl-P-(2-phthalimidoethyl)phosphinsaeureamid

There total 4 articles about N-(2-Mercaptoethyl)-P-phenyl-P-(2-phthalimidoethyl)phosphinsaeureamid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.8%

2-mercaptoethylamine hydrochloride (156-57-0) + C16H13ClNO3P → N-(2-Mercaptoethyl)-P-phenyl-P-(2-phthalimidoethyl)phosphinsaeureamid (160194-57-0)

Guidance literature:

With triethylamine; In chloroform; for 4h; Heating;

DOI:10.1002/hlca.19940770612

Reference yield:

2-(2-bromoethyl)isoindoline-1,3-dione (574-98-1) → N-(2-Mercaptoethyl)-P-phenyl-P-(2-phthalimidoethyl)phosphinsaeureamid (160194-57-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 51 percent / 170 deg C, 4 h; 120 deg C, 3 h

2: PCl₅ / toluene / 12 h / Heating

3: 34.8 percent / Et₃N / CHCl₃ / 4 h / Heating

With phosphorus pentachloride; triethylamine; In chloroform; toluene;

DOI:10.1002/hlca.19940770612

Reference yield:

potassium phtalimide (1074-82-4) → N-(2-Mercaptoethyl)-P-phenyl-P-(2-phthalimidoethyl)phosphinsaeureamid (160194-57-0)

Guidance literature:

Multi-step reaction with 4 steps

1: acetone / 16 h / Heating

2: 51 percent / 170 deg C, 4 h; 120 deg C, 3 h

3: PCl₅ / toluene / 12 h / Heating

4: 34.8 percent / Et₃N / CHCl₃ / 4 h / Heating

With phosphorus pentachloride; triethylamine; In chloroform; acetone; toluene;

DOI:10.1002/hlca.19940770612

upstream raw materials:

2-mercaptoethylamine hydrochloride

2-(2-bromoethyl)isoindoline-1,3-dione

potassium phtalimide

Phenyl(2-phthalimidoethyl)phosphinsaeure-ethylester

Downstream raw materials:

C₁₀H₁₇N₂OPS