2-Sulfanylethylazanium;chloride

Base Information

• Chemical Name: 2-Sulfanylethylazanium;chloride
• CAS No.: 156-57-0
• Molecular Formula: C2H7NS^.HCl
• Molecular Weight: 113.611
• Hs Code.: 29309070
• Mol file: 156-57-0.mol

Synonyms:2-sulfanylethylazanium;chloride;2-aminoethanethiol;hydron;2-mercaptoethanaminium chloride

Chemical Property of 2-Sulfanylethylazanium;chloride

Chemical Property:

• Appearance/Colour: white crystalline powder with a strong and disagreeable smell
• Vapor Pressure: 16.7mmHg at 25°C
• Melting Point: 66-70 °C
• Refractive Index: 1.6100 (estimate)
• Boiling Point: 133.6 °C at 760 mmHg
• Flash Point: 34.6 °C
• PSA: 64.82000
• Density: 0.75 g/cm³
• LogP: 1.37720
• Storage Temp.: 2-8°C
• Sensitive.: Hygroscopic
• Solubility.: H2O: 1 m at 20 °C, clear, colorless
• Water Solubility.: VERY SOLUBLE
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 113.0065981
• Heavy Atom Count: 5
• Complexity: 10

Purity/Quality:

99.5% Min. ^*data from raw suppliers

Cysteamine hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn,Xi
• Statements: 22-36/37/38
• Safety Statements: 36/37/39-26-36

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C(CS)[NH3+].[Cl-]
• Description: Cysteamine is a stable aminothiol with radioprotective activities. It reduces ionizing radiation-induced death and chromosomal damage in mice in a dose-dependent manner. Cysteamine binds rapidly and temporarily to plasma proteins upon administration and this activity is directly correlated to its radioprotective effects. In vitro, 0.1 mM cysteamine depletes 90% of free cystine from cystinotic fibroblasts. Formulations containing cysteamine have been used to treat nephropathic cystinosis and reduce glomerular deterioration in humans.
• Uses: Cysteamine hydrochloride is used as an antioxidant and in radiation therapy. Cysteamine hydrochloride has been used in the in-situ generation of chiral cysteamine-capped cadmium sulfide quantum dots (CA-CdS QDs) for the sensing of Cd2+ and S2-. An inhibitor of DMBA-induced mammary tumors2-Mercaptoethylamine hydrochloride acts as a precursor in taurine biosynthesis and component of coenzyme A. It is involved in the preparation of active pharmaceutical ingredients like ranitidine and nizatidine. It acts as an antidote for acetaminophen poisoning. Further, it is used in the oral treatment of nephropathic cystinosis, radiation sickness and disorders of cysteine excretion. In addition to this, it serves as an antioxidant and an inhibitor of 7,12-Dimethylbenz[a]anthracene (DMBA)-induced tumors.

Technology Process of 2-Sulfanylethylazanium;chloride

There total 19 articles about 2-Sulfanylethylazanium;chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.6%

2-mercaptothiazoline (96-53-7) → 2-mercaptoethylamine hydrochloride (156-57-0)

Guidance literature:

With hydrogenchloride; water; for 7h; under 2250.23 Torr; Reflux;

Reference yield: 95.0%

2-chloroethanamine hydrochloride (870-24-6) → 2-mercaptoethylamine hydrochloride (156-57-0)

Guidance literature:

2-chloroethanamine hydrochloride; With sodium thiocarbonate; In water; at 40 - 60 ℃;

With hydrogenchloride; In water; at 70 - 85 ℃;

Reference yield: 93.5%

sodium 2‐aminoethyl sulfate (666-03-5) → 2-mercaptoethylamine hydrochloride (156-57-0)

Guidance literature:

sodium 2‐aminoethyl sulfate; With sodium thiocarbonate; In water; at 40 - 60 ℃;

With hydrogenchloride; In water; at 70 - 85 ℃;

upstream raw materials:

N-(2-mercaptoethyl)-phthalimide

thiazolidine-2-thione

L-alanin

hydrochloride salt of (1-chloro-2-acetylamino-2-methyl-1-phenylpropyl) 2-aminoethyl sulfide

Downstream raw materials:

1,3-thiazolidine

thiazolidine hydrochloride

thiolauric acid S-(2-amino-ethyl ester); hydrochloride

S-benzoylcysteamine hydrochloride

Refernces

• 1、 El-Sayed, Naglaa Salem,Shirazi, Amir Nasrolahi,Sajid, Muhammad Imran,Park, Shang Eun,Parang, Keykavous,Tiwari, Rakesh Kumar. "Synthesis and antiproliferative activities of conjugates of paclitaxel and camptothecin with a cyclic cell-penetrating peptide". . . Retrieved 2019/04/30.
• 2、 -. "PROCESS FOR THE PREPARATION OF A SULFUR-AMINE". Paragraph 0040; 0041. . Retrieved 2018/05/03.