Technology Process of 3-bromotricetin 3',4',5'-trimethyl ether
There total 1 articles about 3-bromotricetin 3',4',5'-trimethyl ether which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
5,7-dihydroxy-3',4',5'-trimethoxyflavone;
With
pyridine; acetic anhydride;
at 20 ℃;
for 72h;
With
N-Bromosuccinimide;
In
methanol; dichloromethane;
at 20 ℃;
for 3h;
With
sodium hydroxide;
In
tetrahydrofuran;
at 20 ℃;
for 3h;
DOI:10.1016/j.tet.2006.02.024
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: potassium carbonate / dimethylformamide / 20 h / 20 °C
2.1: 237 mg / KHCO3 / dimethylformamide / 2 h / 120 °C
3.2: 12 percent / Fe(acac)3 / tetrahydrofuran / 3 h / -30 - -20 °C
4.1: 100 percent / hydrogen / Pd-C / tetrahydrofuran / 3 h / 20 °C
With
hydrogen; potassium carbonate; potassium hydrogencarbonate;
palladium on activated charcoal;
In
tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2006.02.024
- Guidance literature:
-
Multi-step reaction with 3 steps
1: potassium carbonate / dimethylformamide / 20 h / 20 °C
2: 237 mg / KHCO3 / dimethylformamide / 2 h / 120 °C
3: 21 percent / potassium carbonate / tetrakis(triphenylphosphine)palladium(0) / dioxane / 110 °C
With
potassium carbonate; potassium hydrogencarbonate;
tetrakis(triphenylphosphine) palladium(0);
In
1,4-dioxane; N,N-dimethyl-formamide;
3: Suzuki-cross coupling;
DOI:10.1016/j.tet.2006.02.024
