2-(2-N,N-diethylcarbamoyl-6-methoxyphenyl)-5-methoxy-1,3-naphthalenediol

Base Information

• Chemical Name: 2-(2-N,N-diethylcarbamoyl-6-methoxyphenyl)-5-methoxy-1,3-naphthalenediol
• CAS No.: 122775-49-9
• Molecular Formula: C₂₃H₂₅NO₅
• Molecular Weight: 395.455
• Mol file: 122775-49-9.mol

Synonyms:2-(2-N,N-diethylcarbamoyl-6-methoxyphenyl)-5-methoxy-1,3-naphthalenediol

Chemical Property of 2-(2-N,N-diethylcarbamoyl-6-methoxyphenyl)-5-methoxy-1,3-naphthalenediol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(2-N,N-diethylcarbamoyl-6-methoxyphenyl)-5-methoxy-1,3-naphthalenediol

There total 3 articles about 2-(2-N,N-diethylcarbamoyl-6-methoxyphenyl)-5-methoxy-1,3-naphthalenediol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

methyl 2-<ω-(2-N,N-diethylcarbamoyl-6-methoxyphenyl)acetyl>-6-methoxyphenylacetate (122775-43-3) → 2-(2-N,N-diethylcarbamoyl-6-methoxyphenyl)-5-methoxy-1,3-naphthalenediol (122775-49-9)

Guidance literature:

With sodium methylate; In methanol; for 18h; Heating;

DOI:10.1248/cpb.37.292

Reference yield:

N,N-diethyl-3-methoxy-2-methylbenzamide (121425-20-5) → 2-(2-N,N-diethylcarbamoyl-6-methoxyphenyl)-5-methoxy-1,3-naphthalenediol (122775-49-9)

Guidance literature:

Multi-step reaction with 3 steps

1: LDA / tetrahydrofuran; hexane / Ambient temperature

2: diethyl ether

3: 63 percent / NaOMe / methanol / 18 h / Heating

With sodium methylate; lithium diisopropyl amide; In tetrahydrofuran; methanol; diethyl ether; hexane;

DOI:10.1248/cpb.37.292

Reference yield:

{2-[2-(2-Diethylcarbamoyl-6-methoxy-phenyl)-acetyl]-6-methoxy-phenyl}-acetic acid → 2-(2-N,N-diethylcarbamoyl-6-methoxyphenyl)-5-methoxy-1,3-naphthalenediol (122775-49-9)

Guidance literature:

Multi-step reaction with 2 steps

1: diethyl ether

2: 63 percent / NaOMe / methanol / 18 h / Heating

With sodium methylate; In methanol; diethyl ether;

DOI:10.1248/cpb.37.292

upstream raw materials:

methyl 2-<ω-(2-N,N-diethylcarbamoyl-6-methoxyphenyl)acetyl>-6-methoxyphenylacetate

N,N-diethyl-3-methoxy-2-methylbenzamide

Downstream raw materials:

2-(3-Hydroxy-5-methoxy-1,4-dioxo-1,4-dihydro-naphthalen-2-yl)-3-methoxy-benzoic acid

2-(2-N,N-diethylcarbamoyl-6-methoxyphenyl)-3-hydroxy-5-methoxy-1,4-naphthoquinone