11-(2-hydroxyphenyl)-3,3-dimethyl-2,3,4,5,10,11-hexahydro-1H-dibenzo[b,e][1,4]diazepin-1-one

Base Information

• Chemical Name: 11-(2-hydroxyphenyl)-3,3-dimethyl-2,3,4,5,10,11-hexahydro-1H-dibenzo[b,e][1,4]diazepin-1-one
• CAS No.: 82408-11-5
• Molecular Formula: C₂₁H₂₂N₂O₂
• Molecular Weight: 334.418
• Mol file: 82408-11-5.mol

Synonyms:3,3-Ddimethyl-2,3,4,5,10,11-hexahydro-11-[(2-hydroxy)phenyl]-1H-dibenzo[b,e][1,4]diazepin-1-one

Chemical Property of 11-(2-hydroxyphenyl)-3,3-dimethyl-2,3,4,5,10,11-hexahydro-1H-dibenzo[b,e][1,4]diazepin-1-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 11-(2-hydroxyphenyl)-3,3-dimethyl-2,3,4,5,10,11-hexahydro-1H-dibenzo[b,e][1,4]diazepin-1-one

There total 5 articles about 11-(2-hydroxyphenyl)-3,3-dimethyl-2,3,4,5,10,11-hexahydro-1H-dibenzo[b,e][1,4]diazepin-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

salicylaldehyde (90-02-8) + dimedone (126-81-8) + 1,2-diamino-benzene (95-54-5) → 3,3-Ddimethyl-2,3,4,5,10,11-hexahydro-11-[(2-hydroxy)phenyl]-1H-dibenzo[b,e][1,4]diazepin-1-one (82408-11-5)

Guidance literature:

With silica-supported nickel oxide nanocomposites; In ethanol; at 70 ℃; for 0.166667h; Microwave irradiation; Green chemistry;

DOI:10.1039/c6nj04013f

Reference yield: 75.0%

salicylaldehyde (90-02-8) + 3-[(2-aminophenyl)amino]-5,5-dimethylcyclohex-2-en-1-one (39222-69-0) → 3,3-Ddimethyl-2,3,4,5,10,11-hexahydro-11-[(2-hydroxy)phenyl]-1H-dibenzo[b,e][1,4]diazepin-1-one (82408-11-5)

Guidance literature:

In ethanol; at 20 ℃;

DOI:10.1055/s-0036-1590306

Reference yield:

dimedone (3471-13-4) → 3,3-Ddimethyl-2,3,4,5,10,11-hexahydro-11-[(2-hydroxy)phenyl]-1H-dibenzo[b,e][1,4]diazepin-1-one (82408-11-5)

Guidance literature:

Multi-step reaction with 2 steps

1: AcOH / propan-2-ol / 0.67 h / Heating

2: propan-2-ol / Heating

With acetic acid; In isopropyl alcohol;

DOI:10.1007/s10593-005-0098-3

upstream raw materials:

2-methyl-benzyl alcohol

3-[(2-aminophenyl)amino]-5,5-dimethylcyclohex-2-en-1-one

dimedone

1,2-diamino-benzene