4-(2'-methoxy-phenyl)-1-[2'-(N-2-pyridyl)-p-aminobenzamido]-ethyl-piperazine

Base Information

• Chemical Name: 4-(2'-methoxy-phenyl)-1-[2'-(N-2-pyridyl)-p-aminobenzamido]-ethyl-piperazine
• CAS No.: 159279-56-8
• Molecular Formula: C₂₅H₂₉N₅O₂
• Molecular Weight: 431.538
• Mol file: 159279-56-8.mol

Synonyms:4-(2'-methoxy-phenyl)-1-[2'-(N-2-pyridyl)-p-aminobenzamido]-ethyl-piperazine

Chemical Property of 4-(2'-methoxy-phenyl)-1-[2'-(N-2-pyridyl)-p-aminobenzamido]-ethyl-piperazine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(2'-methoxy-phenyl)-1-[2'-(N-2-pyridyl)-p-aminobenzamido]-ethyl-piperazine

There total 1 articles about 4-(2'-methoxy-phenyl)-1-[2'-(N-2-pyridyl)-p-aminobenzamido]-ethyl-piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

p-MPPN (155204-27-6) → 4-(2'-methoxy-phenyl)-1-[2'-(N-2-pyridyl)-p-aminobenzamido]-ethyl-piperazine (159279-56-8)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; ethyl acetate; under 2068.6 Torr; Ambient temperature;

DOI:10.1021/jm00052a018

Reference yield: 82.0%

thiophosgene (463-71-8) + 4-(2'-methoxy-phenyl)-1-[2'-(N-2-pyridyl)-p-aminobenzamido]-ethyl-piperazine (159279-56-8) → 4-(2'-methoxy-phenyl)-1-[2'-(N-2-pyridyl)-p-isothiocyanobenzamido]-ethyl-piperazine

Guidance literature:

With sodium hydrogencarbonate; In toluene; at 20 ℃; for 0.75h;

DOI:10.1016/0024-3205(95)02275-9

Reference yield: 78.0%

chloroacetyl chloride (79-04-9) + 4-(2'-methoxy-phenyl)-1-[2'-(N-2-pyridyl)-p-aminobenzamido]-ethyl-piperazine (159279-56-8) → 4-(2-Chloro-acetylamino)-N-{2-[4-(2-methoxy-phenyl)-piperazin-1-yl]-ethyl}-N-pyridin-2-yl-benzamide

Guidance literature:

With triethylamine; In dichloromethane; for 1h; Ambient temperature;

DOI:10.1021/jm00052a018

upstream raw materials:

p-MPPN